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Glud1 glutamate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24399, updated on 27-Nov-2024

Summary

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Official Symbol
Glud1provided by RGD
Official Full Name
glutamate dehydrogenase 1provided by RGD
Primary source
RGD:2708
See related
EnsemblRapid:ENSRNOG00000057367 AllianceGenome:RGD:2708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gdh1; Glud; MRG-2; Ac2-281; Gludeha
Summary
Enables enzyme binding activity and glutamate dehydrogenase (NAD+) activity. Involved in cerebellum development; long-term memory; and response to aluminum ion. Predicted to be located in endoplasmic reticulum and mitochondrial matrix. Predicted to be active in mitochondrion. Biomarker of brain disease (multiple) and fascioliasis. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 2449.8), Kidney (RPKM 1287.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glud1 in Genome Data Viewer
Location:
16p15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9646569..9680215)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9640312..9673961)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10661486..10695557)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 2 Neighboring gene ZW10 interacting kinetochore protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene family with sequence similarity 25, member A Neighboring gene synuclein, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the rat gene encoding glutamate dehydrogenase. Das AT, et al. Eur J Biochem, 1993 Feb 1. PMID 8094669
  2. Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy. Thomas JW, et al. Metab Brain Dis, 1988 Jun. PMID 2903433
  3. Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain. Korolainen MA, et al. Neurobiol Aging, 2006 Jan. PMID 16298240
  4. Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients. Burbaeva GSh, et al. Neurochem Res, 2005 Nov. PMID 16341942
  5. Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats. Hołownia A, et al. Mater Med Pol, 1994 Jan-Mar. PMID 7808037

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of alpha-ketoglutarate level.
    Title: GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level.
  2. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
    Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
  3. Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma.
    Title: Effects of low-dose radiation on glutamate dehydrogenase activity in tissues of rats with transplanted Guerin's carcinoma.
  4. We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis
    Title: Glutamate dehydrogenase 1 and SIRT4 regulate glial development.
  5. GDH activity is involved in activation of insulin secretion.
    Title: Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome.
  6. GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate.
    Title: Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
  7. inhibition of glutamate dehydrogenase results in sulfite neurotoxicity
    Title: A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase.
  8. during acidosis, the pH-responsive stabilization of glutamate dehydrogenase mRNA may be accomplished by the same mechanism that affects an increase in mitochondrial glutaminase mRNA
    Title: pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93608

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables glutamate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate dehydrogenase [NAD(P)+] activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glutamate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-term memory IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to aluminum ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in tricarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamate dehydrogenase 1, mitochondrial
Names
memory-related gene 2 protein
NP_036702.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012570.2 → NP_036702.1  glutamate dehydrogenase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036702.1

    Status: VALIDATED

    Source sequence(s)
    BC081841, JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P10860, Q66HI8, Q6LC16
    UniProtKB/TrEMBL
    A0A8I6AGI7, A6KFS5
    Related
    ENSRNOP00000104584.1, ENSRNOT00000137721.1
    Conserved Domains (3) summary
    cd01076
    Location:263 → 548
    NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
    COG0334
    Location:104 → 546
    GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
    pfam02812
    Location:113 → 240
    ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    9646569..9680215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10860.2 GenPept UniProtKB/Swiss-Prot:P10860

Gene LinkOut

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