Gstm1 glutathione S-transferase mu 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gstm1provided by RGD
Official Full Name: glutathione S-transferase mu 1provided by RGD
Primary source: RGD:2755
See related: EnsemblRapid:ENSRNOG00000029726 AllianceGenome:RGD:2755
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GSTA3
Summary: Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1582.2), Testes (RPKM 556.6) and 7 other tissues See more
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198338005..198346007, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195649845..195655402, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210803869..210809461, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data support the hypothesis that reduced renal Gstm1 plays a role in the development of hypertension.
Title: Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat.
GST-facilitated S-glutathionylation of AMPK may be involved in rapid, full activation of the kinase under mildly oxidative physiological conditions.
Title: Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro.
GSTM1 and glutathione S-transferase theta;1 (GSTT1) null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke.
Title: Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk.
This protein has been found differentially expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
Title: Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
the mu loop is not essential for GST M1 to maintain its structure nor is it required for the enzyme to retain some catalytic activity. However, it is an important determinant of the enzyme's affinity for its substrates.
Title: Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1.
These results indicate that rats that are polymorphic for the GST M1 gene exhibit different susceptibilities to CF in vivo.
Title: Different susceptibility to peroxisome proliferator-induced hepatocarcinogenesis in rats with polymorphic glutathione transferase genes.
The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium
Title: Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons.
Data describe the conformational stability of the chimeric homodimers M(12)-(12) and M(21)-(21) constructed from glutathione transferases M1-1 and M2-2.
Title: Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases.
Simultaneous disruption of both motifs in the F56S/R81A mutant causes complete dissociation of the dimer to a monomeric protein on the basis of gel filtration chromatography and multiple-angle laser light scattering.
Title: Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.
circulating testosterone or one of its metabolites regulates expression of Yb(1)-GST in basal cells of the corpus region indicating a differential regulation with respect to expression in the various cell types and regions of the epididymis.
Title: Immunolocalization of the Yb1 subunit of glutathione S-transferase in the adult rat epididymis following orchidectomy and efferent duct ligation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Got198 (e-PCR)
- UniSTS:114043

BI281611 (e-PCR)
- UniSTS:249529

Gstm1 (e-PCR), detects polymorphism
- UniSTS:526843

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	IDA Inferred from Direct Assay more info	PubMed
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in glutathione derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione derivative biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitrobenzene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase Mu 1

Names: GST 3-3; GST Yb1; GSTM1-1; glutathione S-transferase M1; glutathione S-transferase Yb-1 subunit; glutathione-S-transferase, mu type 1 (Yb1)

NP_058710.2

EC 2.5.1.18

XP_038957642.1

EC 2.5.1.18

XP_063137360.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017014.2 → NP_058710.2 glutathione S-transferase Mu 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P04905

UniProtKB/TrEMBL

A6HUX0, G3V983

Related

ENSRNOP00000039050.3, ENSRNOT00000047139.5

Conserved Domains (2) summary

cd03209
Location:92 → 211

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198338005..198346007 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101714.2 → XP_038957642.1 glutathione S-transferase Mu 1 isoform X1

Conserved Domains (2) summary

cd03209
Location:43 → 162

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cl00388
Location:3 → 37

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
XM_063281290.1 → XP_063137360.1 glutathione S-transferase Mu 1 isoform X2