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Myo16 myosin XVI [ Mus musculus (house mouse) ]

Gene ID: 244281, updated on 27-Nov-2024

Summary

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Official Symbol
Myo16provided by MGI
Official Full Name
myosin XVIprovided by MGI
Primary source
MGI:MGI:2685951
See related
Ensembl:ENSMUSG00000039057 AllianceGenome:MGI:2685951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NYAP3; Gm1105; mKIAA0865; C230040D10Rik
Summary
Predicted to enable actin filament binding activity and protein phosphatase binding activity. Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of myosin complex. Predicted to be active in nucleoplasm and perinuclear region of cytoplasm. Is expressed in central nervous system; metanephros; and white fat. Orthologous to human MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 7.1), CNS E18 (RPKM 3.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Myo16 in Genome Data Viewer
Location:
8 A1.1; 8 4.77 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10203911..10684742)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10153911..10634742)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 13b Neighboring gene predicted gene 44788 Neighboring gene STARR-seq mESC enhancer starr_20696 Neighboring gene predicted gene, 51560 Neighboring gene STARR-seq mESC enhancer starr_20697 Neighboring gene predicted gene, 51561 Neighboring gene STARR-seq mESC enhancer starr_20698 Neighboring gene predicted gene, 32330 Neighboring gene predicted gene 44785

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Roesler MK, et al. Front Cell Neurosci, 2019. PMID 31474830, Free PMC Article
  2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
  3. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
  4. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Piniella D, et al. Cell Mol Life Sci, 2021 Dec. PMID 34709416, Free PMC Article
  5. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0865

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
unconventional myosin-XVI
Names
neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 3
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
unconventional myosin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319151.1 → NP_001306080.1  unconventional myosin-XVI

    Status: VALIDATED

    Source sequence(s)
    AK034257, BC072580, BC082311, BC172122
    Consensus CDS
    CCDS40218.2
    UniProtKB/Swiss-Prot
    B2RX94, E1CB68, Q5DU14, Q6GQW7, Q8BUV4
    UniProtKB/TrEMBL
    F8WGF8
    Related
    ENSMUSP00000146677.2, ENSMUST00000207477.2
    Conserved Domains (5) summary
    PHA03095
    Location:70 → 291
    PHA03095; ankyrin-like protein; Provisional
    cd14878
    Location:414 → 1131
    MYSc_Myo16; class XVI myosin, motor domain
    sd00045
    Location:221 → 252
    ANK; ANK repeat [structural motif]
    pfam15439
    Location:1219 → 1583
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:1730 → 1760
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    10203911..10684742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508779.4 → XP_006508842.1  unconventional myosin-XVI isoform X2

    See identical proteins and their annotated locations for XP_006508842.1

    UniProtKB/Swiss-Prot
    B2RX94, E1CB68, Q5DU14, Q6GQW7, Q8BUV4
    UniProtKB/TrEMBL
    F8WGF8
    Conserved Domains (5) summary
    PHA03095
    Location:70 → 291
    PHA03095; ankyrin-like protein; Provisional
    cd14878
    Location:414 → 1131
    MYSc_Myo16; class XVI myosin, motor domain
    sd00045
    Location:221 → 252
    ANK; ANK repeat [structural motif]
    pfam15439
    Location:1219 → 1583
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:1730 → 1760
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  2. XM_006508780.5 → XP_006508843.1  unconventional myosin-XVI isoform X3

    UniProtKB/TrEMBL
    F8WGF8
    Conserved Domains (5) summary
    PHA03095
    Location:92 → 313
    PHA03095; ankyrin-like protein; Provisional
    cd14878
    Location:436 → 1153
    MYSc_Myo16; class XVI myosin, motor domain
    sd00045
    Location:243 → 274
    ANK; ANK repeat [structural motif]
    pfam15439
    Location:1241 → 1605
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:1752 → 1782
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  3. XM_036154016.1 → XP_036009909.1  unconventional myosin-XVI isoform X4

    UniProtKB/TrEMBL
    F8WGF8
    Conserved Domains (4) summary
    PHA03095
    Location:92 → 313
    PHA03095; ankyrin-like protein; Provisional
    cd14878
    Location:436 → 1153
    MYSc_Myo16; class XVI myosin, motor domain
    sd00045
    Location:243 → 274
    ANK; ANK repeat [structural motif]
    pfam15439
    Location:1235 → 1605
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  4. XM_006508778.4 → XP_006508841.1  unconventional myosin-XVI isoform X1

    UniProtKB/TrEMBL
    F8WGF8
    Conserved Domains (5) summary
    PHA03095
    Location:92 → 313
    PHA03095; ankyrin-like protein; Provisional
    cd14878
    Location:436 → 1153
    MYSc_Myo16; class XVI myosin, motor domain
    sd00045
    Location:243 → 274
    ANK; ANK repeat [structural motif]
    pfam15439
    Location:1241 → 1605
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:1752 → 1782
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081397.1: Suppressed sequence

    Description
    NM_001081397.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU14.2 GenPept UniProtKB/Swiss-Prot:Q5DU14

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