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Prag1 PEAK1 related kinase activating pseudokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 244418, updated on 27-Nov-2024

Summary

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Official Symbol
Prag1provided by MGI
Official Full Name
PEAK1 related kinase activating pseudokinase 1provided by MGI
Primary source
MGI:MGI:1196223
See related
Ensembl:ENSMUSG00000050271 AllianceGenome:MGI:1196223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NACK; Sgk223; D8Ertd82e; mFLJ00269; 9830148H23
Summary
Predicted to enable identical protein binding activity and protein kinase activity. Involved in regulation of Notch signaling pathway. Located in nucleus. Is expressed in forebrain; spinal cord; telencephalon; and vibrissa. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in small intestine adult (RPKM 9.2), mammary gland adult (RPKM 8.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Prag1 in Genome Data Viewer
Location:
8 A4; 8 22.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (36562015..36614939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (36094827..36147787)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:37091412-37091733 Neighboring gene ribosomal protein S12, pseudogene 24 Neighboring gene predicted gene, 39163 Neighboring gene STARR-positive B cell enhancer ABC_E8845 Neighboring gene STARR-seq mESC enhancer starr_21199 Neighboring gene STARR-positive B cell enhancer ABC_E5001 Neighboring gene predicted gene, 38414 Neighboring gene STARR-seq mESC enhancer starr_21203 Neighboring gene predicted gene, 39164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Weaver KL, et al. Cancer Res, 2014 Sep 1. PMID 25038227, Free PMC Article
  2. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. Tanaka H, et al. J Biol Chem, 2006 Apr 14. PMID 16481321
  3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  4. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Titz B, et al. Oncogene, 2010 Nov 4. PMID 20697350, Free PMC Article
  5. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Also known as SgK223, a member of the NKF3 family of protein kinases predicted to be catalytically inactive.
    Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00269, MGC100334

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inactive tyrosine-protein kinase PRAG1
Names
notch activation complex kinase
pragmin
sugen kinase 223
tyrosine-protein kinase PRAG1
tyrosine-protein kinase SgK223
NP_001413501.1
NP_766499.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426572.1 → NP_001413501.1  inactive tyrosine-protein kinase PRAG1

    Status: VALIDATED

    Source sequence(s)
    AC121858
    UniProtKB/Swiss-Prot
    E9QLH9, Q571I4, Q8CB68

  2. NM_172911.4 → NP_766499.2  inactive tyrosine-protein kinase PRAG1

    See identical proteins and their annotated locations for NP_766499.2

    Status: VALIDATED

    Source sequence(s)
    AC121858
    Consensus CDS
    CCDS22247.2
    UniProtKB/Swiss-Prot
    E9QLH9, Q571I4, Q8CB68
    Related
    ENSMUSP00000106118.2, ENSMUST00000110492.2
    Conserved Domains (2) summary
    PHA03247
    Location:387 → 603
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:1094 → 1297
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    36562015..36614939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q571I4.3 GenPept UniProtKB/Swiss-Prot:Q571I4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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