Prss35 serine protease 35 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss35provided by MGI
Official Full Name: serine protease 35provided by MGI
Primary source: MGI:MGI:2444800
See related: Ensembl:ENSMUSG00000033491 AllianceGenome:MGI:2444800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P3D9; 6030424L22Rik
Summary: Predicted to enable serine-type endopeptidase activity. Located in mitochondrion. Is expressed in embryo; head; interstitium of the testis; primary palate; and right atrium. Orthologous to human PRSS35 (serine protease 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 17.6), limb E14.5 (RPKM 14.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 46.58 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (86625291..86640496)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (86743240..86758443)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis.
Title: Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis.
The study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development.
Title: Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility.
HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia
Title: Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary.
Prss35 mRNA levels increased around the time of ovulation and remained elevated in the developing corpus luteum
Title: The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies.
Mouse ortholog of human PRSS35 is an ovary-selectively expressed gene.
Title: The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: inactive serine protease 35

Names: protease, serine 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178738.3 → NP_848853.2 inactive serine protease 35 precursor

See identical proteins and their annotated locations for NP_848853.2

Status: VALIDATED

Source sequence(s)

BB659182, BC075675

Consensus CDS

CCDS40714.1

UniProtKB/Swiss-Prot

Q8C0D6, Q8C0F9, Q8C0L5

Related

ENSMUSP00000035271.7, ENSMUST00000036426.13

Conserved Domains (1) summary

cl21584
Location:124 → 389

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

86625291..86640496

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155009.1 → XP_036010902.1 inactive serine protease 35 isoform X1

UniProtKB/Swiss-Prot

Q8C0D6, Q8C0F9, Q8C0L5

Conserved Domains (1) summary

cl21584
Location:124 → 389

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006511170.5 → XP_006511233.1 inactive serine protease 35 isoform X1

See identical proteins and their annotated locations for XP_006511233.1

UniProtKB/Swiss-Prot

Q8C0D6, Q8C0F9, Q8C0L5

Conserved Domains (1) summary

cl21584
Location:124 → 389

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006511171.5 → XP_006511234.1 inactive serine protease 35 isoform X1

See identical proteins and their annotated locations for XP_006511234.1

UniProtKB/Swiss-Prot

Q8C0D6, Q8C0F9, Q8C0L5

Conserved Domains (1) summary

cl21584
Location:124 → 389

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...