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Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24521, updated on 27-Nov-2024

Summary

Symbol
Kcnj1provided by RGD
Full Name
potassium inwardly-rectifying channel, subfamily J, member 1provided by RGD
Primary source
RGD:2957
See related
EnsemblRapid:ENSRNOG00000059005 AllianceGenome:RGD:2957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kcnj; KAB-1; ROMK1; ROMK2; ROMK3; kir1.1; Kcnj1_v1; Kcnj1_v3
Summary
Enables several functions, including ATP binding activity; ATP-activated inward rectifier potassium channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion import across plasma membrane; and response to potassium ion. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 575.3) See more
Orthologs
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Genomic context

See Kcnj1 in Genome Data Viewer
Location:
8q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (39014822..39066716)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30779883..30808607)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33490280..33519127)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 32 Neighboring gene ribosomal protein L35 like 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC134479972

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to magnesium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within circulatory system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of G-protein activated inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in response to potassium ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 1
Names
ATP-regulated potassium channel ROM-K
K+ channel protein
inward rectifier K(+) channel Kir1.1
potassium channel, inwardly rectifying subfamily J member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309297.1NP_001296226.1  ATP-sensitive inward rectifier potassium channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001296226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as ROMK2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O88639, O88640, P35560, Q9QUR5
    UniProtKB/TrEMBL
    A0A8I6AW52, A6JYI0
    Related
    ENSRNOP00000077878.2, ENSRNOT00000110096.2
    Conserved Domains (1) summary
    pfam01007
    Location:24352
    IRK; Inward rectifier potassium channel
  2. NM_001309298.1NP_001296227.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as ROMK6.1) contains two alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K298, A6JYI4
    Related
    ENSRNOP00000072157.2, ENSRNOT00000081525.3
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  3. NM_001309299.1NP_001296228.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as ROMK3.1) contains three alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K298, A6JYI4
    Related
    ENSRNOP00000078843.2, ENSRNOT00000099372.2
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  4. NM_001309301.1NP_001296230.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as ROMK1.1) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K298, A6JYI4
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  5. NM_017023.2NP_058719.2  ATP-sensitive inward rectifier potassium channel 1 isoform 1

    See identical proteins and their annotated locations for NP_058719.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as ROMK1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O88639, O88640, P35560, Q9QUR5
    UniProtKB/TrEMBL
    A0A0G2JYW2, A6JYH9
    Related
    ENSRNOP00000070813.1, ENSRNOT00000081614.3
    Conserved Domains (1) summary
    pfam01007
    Location:43371
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    39014822..39066716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264896.1XP_063120966.1  ATP-sensitive inward rectifier potassium channel 1 isoform X1

  2. XM_063264899.1XP_063120969.1  ATP-sensitive inward rectifier potassium channel 1 isoform X3

  3. XM_063264898.1XP_063120968.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZJL6
  4. XM_063264897.1XP_063120967.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZJL6