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Zdhhc19 zinc finger, DHHC domain containing 19 [ Mus musculus (house mouse) ]

Gene ID: 245308, updated on 27-Nov-2024

Summary

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Official Symbol
Zdhhc19provided by MGI
Official Full Name
zinc finger, DHHC domain containing 19provided by MGI
Primary source
MGI:MGI:2682948
See related
Ensembl:ENSMUSG00000052363 AllianceGenome:MGI:2682948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm616; Gm1744
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of aggrephagy; and protein targeting to membrane. Predicted to be located in Golgi membrane and perinucleolar compartment. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 76.6) See more
Orthologs
human all
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Genomic context

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See Zdhhc19 in Genome Data Viewer
Location:
16 B3; 16 22.76 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32315059..32326032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32496241..32507214)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:32430841-32431142 Neighboring gene STARR-positive B cell enhancer ABC_E9428 Neighboring gene phosphate cytidylyltransferase 1, choline, alpha isoform Neighboring gene solute carrier family 51, alpha subunit Neighboring gene STARR-seq mESC enhancer starr_40658 Neighboring gene STARR-seq mESC enhancer starr_40663 Neighboring gene STARR-seq mESC enhancer starr_40664 Neighboring gene STARR-seq mESC enhancer starr_40665 Neighboring gene SET domain containing 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7444 Neighboring gene transferrin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice. Wang S, et al. Int J Mol Sci, 2021 Aug 18. PMID 34445597, Free PMC Article
  2. ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†. Wu Y, et al. Biol Reprod, 2022 Mar 19. PMID 34897408
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesisdagger.
    Title: ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.
  2. ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice.
    Title: ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC58833

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of aggrephagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of aggrephagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinucleolar compartment IEA
Inferred from Electronic Annotation
more info
  
located_in perinucleolar compartment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC19
Names
DHHC-19
probable palmitoyltransferase ZDHHC19
zinc finger DHHC domain-containing protein 19
NP_955013.1
XP_006522198.1
XP_011244202.1
XP_030104974.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199309.2 → NP_955013.1  palmitoyltransferase ZDHHC19

    See identical proteins and their annotated locations for NP_955013.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140186
    Consensus CDS
    CCDS28122.1
    UniProtKB/Swiss-Prot
    Q810M5
    UniProtKB/TrEMBL
    B9EIU6
    Related
    ENSMUSP00000070727.8, ENSMUST00000064192.8
    Conserved Domains (1) summary
    pfam01529
    Location:109 → 181
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32315059..32326032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249114.1 → XP_030104974.1  palmitoyltransferase ZDHHC19 isoform X2

    Related
    ENSMUSP00000156284.2, ENSMUST00000231510.2
    Conserved Domains (1) summary
    pfam01529
    Location:26 → 82
    DHHC; DHHC palmitoyltransferase

  2. XM_011245900.1 → XP_011244202.1  palmitoyltransferase ZDHHC19 isoform X1

    UniProtKB/TrEMBL
    B9EIU6
    Conserved Domains (1) summary
    pfam01529
    Location:107 → 179
    DHHC; DHHC palmitoyltransferase

  3. XM_006522135.3 → XP_006522198.1  palmitoyltransferase ZDHHC19 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:26 → 82
    DHHC; DHHC palmitoyltransferase

RNA

  1. XR_875803.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810M5.1 GenPept UniProtKB/Swiss-Prot:Q810M5

Gene LinkOut

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