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Polr2h polymerase (RNA) II (DNA directed) polypeptide H [ Mus musculus (house mouse) ]

Gene ID: 245841, updated on 27-Nov-2024

Summary

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Official Symbol
Polr2hprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Hprovided by MGI
Primary source
MGI:MGI:2384309
See related
Ensembl:ENSMUSG00000021018 AllianceGenome:MGI:2384309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 12.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Polr2h in Genome Data Viewer
Location:
16 B1; 16 12.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20536552..20541015)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20717826..20722272)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene STARR-seq mESC enhancer starr_40329 Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene STARR-positive B cell enhancer ABC_E1489 Neighboring gene STARR-seq mESC enhancer starr_40331 Neighboring gene thrombopoietin Neighboring gene chordin Neighboring gene predicted gene, 22741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
  2. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8248, MGC103049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Names
DNA-directed RNA polymerase II subunit H
RNA polymerases I, II, and III subunit ABC3
RPB17
RPB8 homolog
NP_001343352.1
NP_001404166.1
NP_001404167.1
NP_663607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356423.2 → NP_001343352.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT010490
    UniProtKB/TrEMBL
    A0A338P6B4
    Related
    ENSMUSP00000155920.2, ENSMUST00000161038.2
    Conserved Domains (1) summary
    smart00658
    Location:1 → 111
    RPOL8c; RNA polymerase subunit 8

  2. NM_001417237.1 → NP_001404166.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT010490

  3. NM_001417238.1 → NP_001404167.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT010490
    UniProtKB/TrEMBL
    A0A338P6M3
    Related
    ENSMUSP00000155895.2, ENSMUST00000231656.2

  4. NM_145632.3 → NP_663607.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1

    See identical proteins and their annotated locations for NP_663607.1

    Status: VALIDATED

    Source sequence(s)
    CT010490
    Consensus CDS
    CCDS28058.1
    UniProtKB/Swiss-Prot
    Q3TT30, Q923G2
    UniProtKB/TrEMBL
    A0A338P6I2
    Related
    ENSMUSP00000021405.8, ENSMUST00000021405.8
    Conserved Domains (1) summary
    smart00658
    Location:2 → 147
    RPOL8c; RNA polymerase subunit 8

RNA

  1. NR_184434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010490

  2. NR_184435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20536552..20541015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_184436.1: Suppressed sequence

    Description
    NR_184436.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923G2.3 GenPept UniProtKB/Swiss-Prot:Q923G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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