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Amdhd2 amidohydrolase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 245847, updated on 27-Nov-2024

Summary

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Official Symbol
Amdhd2provided by MGI
Official Full Name
amidohydrolase domain containing 2provided by MGI
Primary source
MGI:MGI:2443978
See related
Ensembl:ENSMUSG00000036820 AllianceGenome:MGI:2443978
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730457F11Rik
Summary
Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process. Is expressed in axial skeleton and nucleus pulposus. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 72.5), testis adult (RPKM 49.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Amdhd2 in Genome Data Viewer
Location:
17 A3.3; 17 12.28 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24374807..24382752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24155833..24163733, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E8657 Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42072 Neighboring gene STARR-seq mESC enhancer starr_42074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24274163-24274452 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene netrin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Kroef V, et al. Elife, 2022 Mar 1. PMID 35229715, Free PMC Article
  2. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
  3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-phosphate deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylglucosamine-6-phosphate deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
N-acetylglucosamine-6-phosphate deacetylase
Names
amidohydrolase domain-containing protein 2
glcNAc 6-P deacetylase
putative N-acetylglucosamine-6-phosphate deacetylase
NP_766523.2
XP_036016505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172935.4 → NP_766523.2  N-acetylglucosamine-6-phosphate deacetylase

    See identical proteins and their annotated locations for NP_766523.2

    Status: PROVISIONAL

    Source sequence(s)
    CT010502
    Consensus CDS
    CCDS28475.1
    UniProtKB/Swiss-Prot
    Q8BK10, Q8JZV7
    UniProtKB/TrEMBL
    F7CUP3
    Related
    ENSMUSP00000036141.6, ENSMUST00000040735.12
    Conserved Domains (2) summary
    COG1228
    Location:31 → 401
    HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
    cd00854
    Location:13 → 398
    NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24374807..24382752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160612.1 → XP_036016505.1  N-acetylglucosamine-6-phosphate deacetylase isoform X1

    UniProtKB/TrEMBL
    F6UP77, F7CUP3
    Related
    ENSMUSP00000120520.3, ENSMUST00000129523.3
    Conserved Domains (1) summary
    cd00854
    Location:13 → 442
    NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZV7.1 GenPept UniProtKB/Swiss-Prot:Q8JZV7

Gene LinkOut

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