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Myl3 myosin light chain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24585, updated on 27-Nov-2024

Summary

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Official Symbol
Myl3provided by RGD
Official Full Name
myosin light chain 3provided by RGD
Primary source
RGD:3142
See related
AllianceGenome:RGD:3142
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MLClV; Mylc1v; rVMLC1
Summary
Enables cytoskeletal motor activity. Involved in cardiac muscle contraction and skeletal muscle tissue development. Part of myosin complex. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 23530.7) See more
Orthologs
human mouse all
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Genomic context

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See Myl3 in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119617077..119623215)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110738669..110744814)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119030852..119036996)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 12 Neighboring gene parathyroid hormone 1 receptor Neighboring gene serine protease 42 Neighboring gene uncharacterized LOC120094264 Neighboring gene serine protease 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential synthesis by cultured atrial and ventricular rat cardiac myocytes of myosin light chain isoforms. Brand T, et al. FEBS Lett, 1991 Jun 3. PMID 2044768
  2. Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension. McNally EM, et al. Nucleic Acids Res, 1989 Apr 11. PMID 2717409, Free PMC Article
  3. Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles. Periasamy M, et al. Nucleic Acids Res, 1989 Oct 11. PMID 2798124, Free PMC Article
  4. The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats. Zhong S, et al. Am J Physiol Cell Physiol, 2007 Aug. PMID 17494635
  5. Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction. Yamashita H, et al. Cardiovasc Res, 2003 Dec 1. PMID 14659803

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
    Title: Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
  2. Slowing of shortening velocity in type IIb fibers with hindlimb unloading involves a decrease in the relative amount of Myl3.
    Title: The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93574

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of striated muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
  
located_in A band ISO
Inferred from Sequence Orthology
more info
  
located_in I band IEA
Inferred from Electronic Annotation
more info
  
located_in I band ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin light chain 3
Names
MLC1SB
Myosin light chain 3, alkali, cardiac ventricles
myosin alkali light chain 1, ventricular
myosin, light chain 3, alkali
myosin, light chain 3, alkali; ventricular, skeletal, slow
myosin, light polypeptide 3
ventricular myosin light chain 1
ventricular, skeletal, slow
ventricular/slow twitch myosin alkali light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012606.2 → NP_036738.1  myosin light chain 3

    See identical proteins and their annotated locations for NP_036738.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081832
    UniProtKB/Swiss-Prot
    P16409
    UniProtKB/TrEMBL
    A0A8I5ZM89, A6I3G7
    Conserved Domains (1) summary
    PTZ00184
    Location:49 → 199
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119617077..119623215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243917.5 → XP_006243979.3  myosin light chain 3 isoform X1

    UniProtKB/Swiss-Prot
    P16409
    UniProtKB/TrEMBL
    A0A8I5ZM89, A6I3G7
    Conserved Domains (1) summary
    PTZ00184
    Location:49 → 199
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16409.2 GenPept UniProtKB/Swiss-Prot:P16409

Gene LinkOut

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