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Map7d1 MAP7 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 245877, updated on 27-Nov-2024

Summary

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Official Symbol
Map7d1provided by MGI
Official Full Name
MAP7 domain containing 1provided by MGI
Primary source
MGI:MGI:2384297
See related
Ensembl:ENSMUSG00000028849 AllianceGenome:MGI:2384297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rprc1; Parcc1; Mtap7d1; mKIAA1187
Summary
Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cytoplasm and spindle. Predicted to be active in microtubule cytoskeleton. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; trigeminal ganglion; and trigeminal nerve. Orthologous to human MAP7D1 (MAP7 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 69.4), CNS E11.5 (RPKM 66.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Map7d1 in Genome Data Viewer
Location:
4 D2.2; 4 60.16 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126125960..126150112, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126232167..126256319, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene SH3 domain containing 21 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene STARR-positive B cell enhancer ABC_E6217 Neighboring gene STARR-positive B cell enhancer ABC_E2122 Neighboring gene trafficking protein particle complex 3 Neighboring gene predicted gene, 54258 Neighboring gene collagen, type VIII, alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DCLK1 phosphorylates the microtubule-associated protein MAP7D1 to promote axon elongation in cortical neurons. Koizumi H, et al. Dev Neurobiol, 2017 Apr. PMID 27503845
  2. Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland MA, et al. Mol Cell Proteomics, 2008 Nov. PMID 18614564, Free PMC Article
  3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27585, MGC28498

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAP7 domain-containing protein 1
Names
arginine/proline rich coiled-coil 1
microtubule-associated protein 7 domain containing 1
proline arginine rich coiled coil 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145970.1 → NP_001139442.1  MAP7 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has several in-frame differences in its coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BM944422, BQ713545, BU053928, CA750559, CK617787, CO043023
    Consensus CDS
    CCDS51302.1
    UniProtKB/TrEMBL
    A2AJI1
    Related
    ENSMUSP00000101738.3, ENSMUST00000106132.3
    Conserved Domains (1) summary
    pfam05672
    Location:517 → 663
    MAP7; MAP7 (E-MAP-115) family

  2. NM_001347198.1 → NP_001334127.1  MAP7 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL732624
    Consensus CDS
    CCDS84793.1
    UniProtKB/TrEMBL
    A8Y5P4
    Related
    ENSMUSP00000113250.2, ENSMUST00000122129.8

  3. NM_001379090.1 → NP_001366019.1  MAP7 domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732624
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:314 → 603
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:588 → 732
    MAP7; MAP7 (E-MAP-115) family

  4. NM_001379091.1 → NP_001366020.1  MAP7 domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732624
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:298 → 497
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:556 → 700
    MAP7; MAP7 (E-MAP-115) family

  5. NM_001379092.1 → NP_001366021.1  MAP7 domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732624
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:280 → 569
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:554 → 698
    MAP7; MAP7 (E-MAP-115) family

  6. NM_001379093.1 → NP_001366022.1  MAP7 domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL732624
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:277 → 566
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:551 → 695
    MAP7; MAP7 (E-MAP-115) family

  7. NM_001379094.1 → NP_001366023.1  MAP7 domain-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL732624
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:264 → 463
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:522 → 666
    MAP7; MAP7 (E-MAP-115) family

  8. NM_144941.3 → NP_659190.3  MAP7 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_659190.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BM944422, BM944941, BU053928, CA750559, CK617787, CO043023, CV563343
    Consensus CDS
    CCDS18646.1
    UniProtKB/Swiss-Prot
    A2AJI0, Q80TI3, Q8CIL3, Q8VCG2, Q91YQ4
    Related
    ENSMUSP00000054338.9, ENSMUST00000061143.15
    Conserved Domains (3) summary
    PTZ00121
    Location:90 → 223
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:317 → 606
    PHA03247; large tegument protein UL36; Provisional
    pfam05672
    Location:591 → 735
    MAP7; MAP7 (E-MAP-115) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126125960..126150112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJI0.1 GenPept UniProtKB/Swiss-Prot:A2AJI0

Gene LinkOut

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