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Chodl chondrolectin [ Mus musculus (house mouse) ]

Gene ID: 246048, updated on 27-Nov-2024

Summary

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Official Symbol
Chodlprovided by MGI
Official Full Name
chondrolectinprovided by MGI
Primary source
MGI:MGI:2179069
See related
Ensembl:ENSMUSG00000022860 AllianceGenome:MGI:2179069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT75; PRED12; 3110074E07Rik
Summary
Predicted to enable carbohydrate binding activity. Acts upstream of or within regulation of neuron projection development. Predicted to be located in centrosome; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Orthologous to human CHODL (chondrolectin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 14.3), bladder adult (RPKM 7.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Chodl in Genome Data Viewer
Location:
16 C3.1; 16 45.39 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78727729..78748624)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78930841..78951736)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41311 Neighboring gene predicted gene, 24861 Neighboring gene RIKEN cDNA 4930570E03 gene Neighboring gene STARR-seq mESC enhancer starr_41312 Neighboring gene STARR-seq mESC enhancer starr_41313 Neighboring gene STARR-seq mESC enhancer starr_41314 Neighboring gene STARR-seq mESC enhancer starr_41315 Neighboring gene transmembrane protease, serine 15 Neighboring gene STARR-seq mESC enhancer starr_41316 Neighboring gene STARR-seq mESC enhancer starr_41317 Neighboring gene STARR-seq mESC enhancer starr_41318 Neighboring gene STARR-seq mESC enhancer starr_41319 Neighboring gene aldo-keto reductase family 1, member D1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of chondrolectin (Chodl), a novel C-type lectin predominantly expressed in muscle cells. Weng L, et al. Gene, 2003 Apr 10. PMID 12711387
  2. The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase. Claessens A, et al. Cell Mol Biol Lett, 2008. PMID 18161010, Free PMC Article
  3. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. Weng L, et al. Genomics, 2002 Jul. PMID 12079284
  4. The organization of submodality-specific touch afferent inputs in the vibrissa column. Sakurai K, et al. Cell Rep, 2013 Oct 17. PMID 24120861, Free PMC Article
  5. Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells. Enjin A, et al. J Comp Neurol, 2010 Jun 15. PMID 20437528

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
    Title: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
  2. Chodl expression exacerbates reduction in cell viability owing to low Smn levels.
    Title: Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.
  3. we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERRbeta) is a candidate marker for slow motor neurons in the spinal cord
    Title: Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells.
  4. The function of chodl was investigated by searching for its protein interaction partners.
    Title: The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables hyaluronic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
chondrolectin
Names
transmembrane protein MT75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362555.1 → NP_001349484.1  chondrolectin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC114925, AC161815
    Consensus CDS
    CCDS88954.1
    UniProtKB/TrEMBL
    B7ZMQ3, F2Z3Y6
    Related
    ENSMUSP00000156041.2, ENSMUST00000232415.2
    Conserved Domains (1) summary
    cl02432
    Location:28 → 180
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. NM_139134.5 → NP_624360.2  chondrolectin isoform 1 precursor

    See identical proteins and their annotated locations for NP_624360.2

    Status: VALIDATED

    Source sequence(s)
    AC114925, AC161815
    Consensus CDS
    CCDS28279.1
    UniProtKB/Swiss-Prot
    Q3US20, Q8BVU2, Q8VI31, Q9CXM0
    UniProtKB/TrEMBL
    F2Z3Y6
    Related
    ENSMUSP00000023568.8, ENSMUST00000023568.14
    Conserved Domains (1) summary
    cl02432
    Location:28 → 180
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    78727729..78748624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523030.4 → XP_006523093.1  chondrolectin isoform X1

    See identical proteins and their annotated locations for XP_006523093.1

    UniProtKB/TrEMBL
    F2Z3Y6
    Related
    ENSMUSP00000063961.7, ENSMUST00000069148.13
    Conserved Domains (1) summary
    cl02432
    Location:28 → 180
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. XM_006523031.4 → XP_006523094.1  chondrolectin isoform X2

    UniProtKB/TrEMBL
    F2Z3Y6
    Conserved Domains (1) summary
    cl02432
    Location:28 → 180
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  3. XM_006523032.3 → XP_006523095.1  chondrolectin isoform X3

    UniProtKB/TrEMBL
    F2Z3Y6
    Conserved Domains (1) summary
    cl02432
    Location:28 → 180
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXM0.3 GenPept UniProtKB/Swiss-Prot:Q9CXM0

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