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Nexn nexilin (F actin binding protein) [ Rattus norvegicus (Norway rat) ]

Gene ID: 246172, updated on 4-Jan-2025

Summary

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Official Symbol
Nexnprovided by RGD
Official Full Name
nexilin (F actin binding protein)provided by RGD
Primary source
RGD:708354
See related
EnsemblRapid:ENSRNOG00000012512 AllianceGenome:RGD:708354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 446.3), Heart (RPKM 437.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nexn in Genome Data Viewer
Location:
2q45
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243846736..243878268, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241186783..241218315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257452937..257484607, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene far upstream element binding protein 1 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene mitoguardin 1 Neighboring gene uncharacterized LOC120100974 Neighboring gene ubiquitin specific peptidase 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells. Lee A, et al. PLoS One, 2013. PMID 23383252, Free PMC Article
  2. NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion. Wang W, et al. Biochem Biophys Res Commun, 2005 May 20. PMID 15823560
  3. Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway. Wang C, et al. Genet Mol Res, 2014 Jul 4. PMID 25062485
  4. Nexilin: a novel actin filament-binding protein localized at cell-matrix adherens junction. Ohtsuka T, et al. J Cell Biol, 1998 Nov 30. PMID 9832551, Free PMC Article
  5. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Hassel D, et al. Nat Med, 2009 Nov. PMID 19881492

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
    Title: Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
  2. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
    Title: Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of muscle IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-substrate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nexilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139230.2 → NP_631976.1  nexilin isoform b

    See identical proteins and their annotated locations for NP_631976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) encodes the longer isoform (b).
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9Z2J3, Q9Z2J4
    UniProtKB/TrEMBL
    A6HWK8
    Related
    ENSRNOP00000073825.2, ENSRNOT00000083344.3
    Conserved Domains (2) summary
    cd00096
    Location:579 → 646
    Ig; Immunoglobulin domain
    pfam07679
    Location:562 → 651
    I-set; Immunoglobulin I-set domain

  2. NM_139231.2 → NP_631977.1  nexilin isoform s

    See identical proteins and their annotated locations for NP_631977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (s) has multiple differences in the coding region but maintains the reading frame, compared to variant s. This variant encodes isoform s, which is shorter than isoform b.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HWK7
    Related
    ENSRNOP00000058811.4, ENSRNOT00000066780.4
    Conserved Domains (2) summary
    pfam07679
    Location:512 → 601
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:512 → 514
    Ig; Ig strand A [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243846736..243878268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233479.5 → XP_006233541.1  nexilin isoform X1

    See identical proteins and their annotated locations for XP_006233541.1

    UniProtKB/TrEMBL
    A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
    Related
    ENSRNOP00000082246.1, ENSRNOT00000111795.2
    Conserved Domains (3) summary
    PTZ00121
    Location:25 → 549
    PTZ00121; MAEBL; Provisional
    pfam07679
    Location:576 → 665
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:576 → 578
    Ig; Ig strand A [structural motif]

  2. XM_006233485.4 → XP_006233547.1  nexilin isoform X3

    UniProtKB/TrEMBL
    A6HWK7
    Conserved Domains (2) summary
    cd00096
    Location:515 → 582
    Ig; Immunoglobulin domain
    pfam07679
    Location:498 → 587
    I-set; Immunoglobulin I-set domain

  3. XM_039101727.2 → XP_038957655.1  nexilin isoform X2

    UniProtKB/TrEMBL
    A6HWK7
    Conserved Domains (2) summary
    pfam07679
    Location:512 → 601
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:512 → 514
    Ig; Ig strand A [structural motif]

  4. XM_063281296.1 → XP_063137366.1  nexilin isoform X3

    UniProtKB/TrEMBL
    A6HWK7

  5. XM_006233480.5 → XP_006233542.1  nexilin isoform X1

    See identical proteins and their annotated locations for XP_006233542.1

    UniProtKB/TrEMBL
    A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
    Conserved Domains (3) summary
    PTZ00121
    Location:25 → 549
    PTZ00121; MAEBL; Provisional
    pfam07679
    Location:576 → 665
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:576 → 578
    Ig; Ig strand A [structural motif]

  6. XM_039101726.2 → XP_038957654.1  nexilin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUL4, A0A8L2QTU4, A6HWK9
    Conserved Domains (3) summary
    PTZ00121
    Location:25 → 549
    PTZ00121; MAEBL; Provisional
    pfam07679
    Location:576 → 665
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:576 → 578
    Ig; Ig strand A [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2J4.1 GenPept UniProtKB/Swiss-Prot:Q9Z2J4

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