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Tax1bp1 Tax1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246244, updated on 4-Jan-2025

Summary

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Official Symbol
Tax1bp1provided by RGD
Official Full Name
Tax1 binding protein 1provided by RGD
Primary source
RGD:708579
See related
EnsemblRapid:ENSRNOG00000008393 AllianceGenome:RGD:708579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aa1076
Summary
Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Involved in negative regulation of apoptotic process. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 592.6), Lung (RPKM 576.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tax1bp1 in Genome Data Viewer
Location:
4q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (83152549..83208463)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81821991..81877906)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (82776720..82832586)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486582 Neighboring gene uncharacterized LOC134486581 Neighboring gene JAZF zinc finger 1 Neighboring gene uncharacterized LOC108350711 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion. Mesentier-Louro LA, et al. Invest Ophthalmol Vis Sci, 2012 Jul 12. PMID 22695963
  2. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Sarraf SA, et al. Mol Cell, 2020 Dec 3. PMID 33207181, Free PMC Article
  3. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. De Valck D, et al. Oncogene, 1999 Jul 22. PMID 10435631
  4. Regulation of NF-κB by ubiquitination. Chen J, et al. Curr Opin Immunol, 2013 Feb. PMID 23312890, Free PMC Article
  5. Deubiquitinases in the regulation of NF-κB signaling. Harhaj EW, et al. Cell Res, 2011 Jan. PMID 21119682, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
    Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
  2. The increased expression of Tax1BP1 in optic nerve crush eyes displays the possible neuroprotective effect of bone marrow mononuclear cell treatment
    Title: Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion.
  3. C-terminal region of Tax1BP1 bound to an intracellular domain of the rho1 subunit, but not to other subunits of GABA(C), GABA(A) or glycine receptors. Tax1BP1 & GABA(C) receptors were co-expressed in both synaptic layers of the retina.
    Title: Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94031

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tax1-binding protein 1 homolog
Names
TRAF6-binding protein homolog
Tax1 (human T-cell leukemia virus type I) binding protein 1
liver regeneration-related protein 2
liver regeneration-related protein LRRG004

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004199.1 → NP_001004199.1  tax1-binding protein 1 homolog

    See identical proteins and their annotated locations for NP_001004199.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081949
    UniProtKB/Swiss-Prot
    Q66HA4, Q7TQ13
    UniProtKB/TrEMBL
    A0A8I6ABW0
    Related
    ENSRNOP00000089029.2, ENSRNOT00000104919.2
    Conserved Domains (5) summary
    TIGR02168
    Location:352 → 641
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07888
    Location:125 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:752 → 778
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    cd21970
    Location:779 → 805
    Zn-C2H2_TAX1BP1_rpt2; second C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    83152549..83208463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236480.5 → XP_006236542.1  tax1-binding protein 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006236542.1

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (2) summary
    pfam07888
    Location:17 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl23720
    Location:171 → 261
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_063285555.1 → XP_063141625.1  tax1-binding protein 1 homolog isoform X5

    UniProtKB/TrEMBL
    A0A8I6ABW0

  3. XM_017592467.3 → XP_017447956.1  tax1-binding protein 1 homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (5) summary
    COG4372
    Location:338 → 669
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam07888
    Location:125 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:728 → 754
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    cl41777
    Location:755 → 781
    Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

  4. XM_006236482.5 → XP_006236544.1  tax1-binding protein 1 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (2) summary
    pfam07888
    Location:17 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl23720
    Location:171 → 261
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. XM_006236483.5 → XP_006236545.1  tax1-binding protein 1 homolog isoform X4

    See identical proteins and their annotated locations for XP_006236545.1

    UniProtKB/TrEMBL
    A0A8I6ABW0, A6K0S8
    Conserved Domains (5) summary
    TIGR02168
    Location:352 → 640
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07888
    Location:125 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:751 → 777
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    cl41777
    Location:778 → 804
    Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

  6. XM_017592468.3 → XP_017447957.1  tax1-binding protein 1 homolog isoform X7

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (5) summary
    COG4372
    Location:338 → 668
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam07888
    Location:125 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:727 → 753
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    cl41777
    Location:754 → 780
    Zn-C2H2_CALCOCO1_TAX1BP1_like; autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins

  7. XM_006236481.5 → XP_006236543.1  tax1-binding protein 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006236543.1

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (2) summary
    pfam07888
    Location:17 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl23720
    Location:171 → 261
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  8. XM_039107045.2 → XP_038962973.1  tax1-binding protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q66HA4, Q7TQ13
    UniProtKB/TrEMBL
    A0A8I6ABW0
    Conserved Domains (5) summary
    TIGR02168
    Location:352 → 641
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07888
    Location:125 → 460
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:752 → 778
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    cd21970
    Location:779 → 805
    Zn-C2H2_TAX1BP1_rpt2; second C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins

  9. XM_063285556.1 → XP_063141626.1  tax1-binding protein 1 homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I6ABW0
    Related
    ENSRNOP00000046052.3, ENSRNOT00000041988.7

  10. XM_063285552.1 → XP_063141622.1  tax1-binding protein 1 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABW0

  11. XM_063285554.1 → XP_063141624.1  tax1-binding protein 1 homolog isoform X4

    UniProtKB/TrEMBL
    A0A8I6ABW0, A6K0S8

  12. XM_063285550.1 → XP_063141620.1  tax1-binding protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABW0

  13. XM_063285553.1 → XP_063141623.1  tax1-binding protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q66HA4, Q7TQ13
    UniProtKB/TrEMBL
    A0A8I6ABW0

  14. XM_063285551.1 → XP_063141621.1  tax1-binding protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABW0

RNA

  1. XR_005503148.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HA4.1 GenPept UniProtKB/Swiss-Prot:Q66HA4

Gene LinkOut

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