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Aspg asparaginase [ Rattus norvegicus (Norway rat) ]

Gene ID: 246266, updated on 27-Nov-2024

Summary

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Official Symbol
Aspgprovided by RGD
Official Full Name
asparaginaseprovided by RGD
Primary source
RGD:708388
See related
EnsemblRapid:ENSRNOG00000012843 AllianceGenome:RGD:708388
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Involved in asparagine metabolic process and phospholipid metabolic process. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 209.9), Kidney (RPKM 170.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Aspg in Genome Data Viewer
Location:
6q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136997832..137017417)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131176727..131196268)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136682279..136701673)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tudor domain containing 9 Neighboring gene RD3 like Neighboring gene fibrillarin, pseudogene 3 Neighboring gene microRNA 3545 Neighboring gene microRNA 203 Neighboring gene kinesin family member 26A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the transacylase activity of rat liver 60-kDa lysophospholipase-transacylase. Acyl transfer from the sn-2 to the sn-1 position. Sugimoto H, et al. Biochim Biophys Acta, 1999 May 18. PMID 10320809
  2. Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat. Sugimoto H, et al. J Biol Chem, 1998 May 15. PMID 9575212
  3. Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver. Sugimoto H, et al. J Biol Chem, 1994 Feb 25. PMID 8119970
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112599

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparaginase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparaginase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparaginase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in asparagine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aspartate family amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
60 kDa lysophospholipase
Names
asparaginase homolog
lysophospholipase
lysophospholipase-transacylase
NP_653351.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144750.2 → NP_653351.1  60 kDa lysophospholipase

    See identical proteins and their annotated locations for NP_653351.1

    Status: PROVISIONAL

    Source sequence(s)
    AB009372
    UniProtKB/Swiss-Prot
    O88202, Q4G088
    UniProtKB/TrEMBL
    A0A0G2JSM2, A6KBU8
    Related
    ENSRNOP00000017454.3, ENSRNOT00000017454.6
    Conserved Domains (3) summary
    PLN03192
    Location:381 → 550
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    cl00216
    Location:15 → 361
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136997832..137017417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005505443.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88202.1 GenPept UniProtKB/Swiss-Prot:O88202

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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