Slc15a4 solute carrier family 15 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc15a4provided by RGD
Official Full Name: solute carrier family 15 member 4provided by RGD
Primary source: RGD:708469
See related: EnsemblRapid:ENSRNOG00000000962 AllianceGenome:RGD:708469
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables L-histidine transmembrane transporter activity. Involved in histidine transport. Predicted to be located in early endosome membrane and endolysosome membrane. Predicted to be active in membrane. Orthologous to human SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 148.8), Kidney (RPKM 82.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (34684583..34718429)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (29048634..29082480)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (32753824..32773277)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells.
Title: Functional expression of SLC15 peptide transporters in rat thyroid follicular cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AA987064 (e-PCR)
- UniSTS:159448

RH141739 (e-PCR)
- UniSTS:223732

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-histidine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-histidine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-histidine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables peptide:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-histidine transmembrane export from vacuole	IEA Inferred from Electronic Annotation more info
involved_in L-histidine transmembrane export from vacuole	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in histidine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in histidine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mast cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mast cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mast cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidoglycan transport	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan transport	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info
involved_in regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in regulation of isotype switching to IgG isotypes	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endolysosome membrane	IEA Inferred from Electronic Annotation more info
located_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
located_in endolysosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 15 member 4

Names: peptide transporter 4; peptide/histidine transporter 1; rPHT1; solute carrier family 15 (oligopeptide transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144758.1 → NP_653359.1 solute carrier family 15 member 4

See identical proteins and their annotated locations for NP_653359.1

Status: PROVISIONAL

Source sequence(s)

AB000280

UniProtKB/Swiss-Prot

O09014, Q5M931

UniProtKB/TrEMBL

A0A0G2JSH0, A6J0U3

Related

ENSRNOP00000001277.2, ENSRNOT00000001277.5

Conserved Domains (1) summary

cd17348
Location:25 → 555

MFS_SLC15A3_4; Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

34684583..34718429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089072.2 → XP_038945000.1 solute carrier family 15 member 4 isoform X3

UniProtKB/TrEMBL

A6J0U4

Conserved Domains (1) summary

cl28910
Location:53 → 295

MFS; Major Facilitator Superfamily
XM_039089071.2 → XP_038944999.1 solute carrier family 15 member 4 isoform X2

Conserved Domains (1) summary

cl28910
Location:18 → 390

MFS; Major Facilitator Superfamily
XM_039089070.2 → XP_038944998.1 solute carrier family 15 member 4 isoform X1

Conserved Domains (1) summary

cl28910
Location:18 → 390

MFS; Major Facilitator Superfamily