Zfp91 zinc finger protein 91 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp91provided by RGD
Official Full Name: zinc finger protein 91provided by RGD
Primary source: RGD:628736
See related: EnsemblRapid:ENSRNOG00000012524 AllianceGenome:RGD:628736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in activation of NF-kappaB-inducing kinase activity; protein K63-linked ubiquitination; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 406.5), Heart (RPKM 360.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (219316002..219353654, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (209891344..209928890, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (229602499..229640906, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH124465 (e-PCR)
- UniSTS:161287

RH127650 (e-PCR)
- UniSTS:210960

RH138194 (e-PCR)
- UniSTS:220281

RH139834 (e-PCR)
- UniSTS:221918

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase ZFP91

Names: cocaine attenuated zinc-finger protein

NP_001162591.1

EC 2.3.2.27

XP_006231189.1

EC 2.3.2.27

XP_063137076.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169120.1 → NP_001162591.1 E3 ubiquitin-protein ligase ZFP91

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AEZ3, F1MAJ8

Related

ENSRNOP00000016804.5, ENSRNOT00000016804.8

Conserved Domains (3) summary

sd00017
Location:345 → 364

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:384 → 409

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:311 → 388

zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

219316002..219353654 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231127.5 → XP_006231189.1 E3 ubiquitin-protein ligase ZFP91 isoform X2

Conserved Domains (3) summary

sd00017
Location:236 → 255

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:275 → 300

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:202 → 279

zf-C2H2_8; C2H2-type zinc ribbon
XM_063281006.1 → XP_063137076.1 E3 ubiquitin-protein ligase ZFP91 isoform X1