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CG30016 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246393, updated on 4-Jan-2025

Summary

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Official Symbol
CG30016provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050016
Locus tag
Dmel_CG30016
See related
AllianceGenome:FB:FBgn0050016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-AE003828.1; Dmel\CG30016
Summary
Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG30016 in Genome Data Viewer
Location:
47C5-47C5; 2-63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10874892..10875392, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6762397..6762897, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45136 Neighboring gene long non-coding RNA:CR44302 Neighboring gene no child left behind Neighboring gene TBP-associated factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. Casper AL, et al. Development, 2011 Aug. PMID 21752937, Free PMC Article
  2. A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis. Gregory SL, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690061
  3. Gene expression in a Drosophila model of mitochondrial disease. Fernández-Ayala DJ, et al. PLoS One, 2010 Jan 6. PMID 20066047, Free PMC Article
  4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydroxyisourate hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG30016-PA
NP_724982.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10874892..10875392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165804.2 → NP_724982.1  uncharacterized protein Dmel_CG30016 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8C9
    Related
    FBpp0087336
    Conserved Domains (1) summary
    pfam00576
    Location:7 → 112
    Transthyretin; HIUase/Transthyretin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8C9 A1Z8C9

Gene LinkOut

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