Pla2g4a phospholipase A2 group 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g4aprovided by RGD
Official Full Name: phospholipase A2 group 4Aprovided by RGD
Primary source: RGD:67366
See related: EnsemblRapid:ENSRNOG00000002657 AllianceGenome:RGD:67366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pla2c; cPLA2; Pla2g4
Summary: Enables calcium-dependent phospholipase A2 activity and histone acetyltransferase binding activity. Involved in several processes, including cellular response to homocysteine; decidualization; and female gonad development. Located in perinuclear region of cytoplasm and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 89.5), Adrenal (RPKM 67.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (64427921..64572352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (61877818..62022261, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (67062252..67206688, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Electroacupuncture improves limb motor function by down-regulating cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells in rats with spinal cord injury].
Title: [Electroacupuncture improves limb motor function by down-regulating cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells in rats with spinal cord injury].
Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Title: Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA2 Activity in Immature Cultured Cortical Preparations.
Title: Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA(2) Activity in Immature Cultured Cortical Preparations.
These results suggest a role of cPLA2 activation in facilitating oligomeric Abeta endocytosis by microglial cells through regulation of the membrane-cytoskeleton connectivity.
Title: Cytosolic Phospholipase A(2) Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity.
Study utilizing glutamate excitotoxicity model in rat cortical primary cell cultures suggests for the first time a more direct action of BACE1 on the hyperphosphorylation state of tau (implemented in Alzheimer's disease pathogenesis) that is mediated through cPLA2 and desaturases SCD1 and FADS6 modulation during glutamate excitotoxicity.
Title: cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures.
UCN counteracted TGF-beta-mediated cPLA2 expression and activation, thereby contributing to TGF-beta-mediated mitoinhibition of VSMCs
Title: UCN enhances TGF-beta-mediated mitoinhibition of VSMCs via counteracting TGF-beta-induced cPLA2 expression and activation.
These data suggest that adaptive changes induced in the myocardium by CIH may include activation of cPLA2alpha and COX-2 via beta2-AR/Gi-mediated stimulation of the ERK/p38 pathway.
Title: Chronic intermittent hypoxia affects the cytosolic phospholipase A(2)α/cyclooxygenase 2 pathway via β(2)-adrenoceptor-mediated ERK/p38 stimulation.
Results showed long-term alteration in protein levels of cPLA2 and clusterin, as well as their downstream autophagy markers Beclin-1, LC3, p62 and Cathepsin-E that is in parallel with cognitive deficits and hippocampal mossy fiber sprouting following recurrent prolonged neonatal seizures, which were restored by chronic ketogenic diet treatment
Title: Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures.
show that accumulation of Abeta induced elevation of APP protein expression mediated by cPLA2 alpha, PGE2 release, and CREB activation via protein kinase A pathway
Title: The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration.
IVA-PLA2 may promote CCl4-induced cell death through the suppression of constitutive autophagy in hepatocytes.
Title: Group IVA phospholipase A(2) deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049522 (e-PCR)
- UniSTS:145969

D13Mgh7 (e-PCR)
- UniSTS:119439

D13Mco2 (e-PCR)
- UniSTS:239834

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate binding	IEA Inferred from Electronic Annotation more info
enables ceramide 1-phosphate binding	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-5-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to antibiotic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in cellular response to homocysteine	IEP Inferred from Expression Pattern more info	PubMed
involved_in decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within icosanoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovulation from ovarian follicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylglycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in platelet activating factor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in platelet activating factor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fever generation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytosolic phospholipase A2

Names: cytosolic phospholipase A2-like; phospholipase A2 cytosolic; phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent)

NP_598235.2

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133551.2 → NP_598235.2 cytosolic phospholipase A2

See identical proteins and their annotated locations for NP_598235.2

Status: VALIDATED

Source sequence(s)

BC070940

UniProtKB/Swiss-Prot

P50393

UniProtKB/TrEMBL

A0A0G2KAA9, Q6IRF5

Related

ENSRNOP00000075329.3, ENSRNOT00000090693.3

Conserved Domains (2) summary

cd07200
Location:144 → 730

cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:20 → 138

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)