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CG30345 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246553, updated on 9-Dec-2024

Summary

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Official Symbol
CG30345provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050345
Locus tag
Dmel_CG30345
See related
AllianceGenome:FB:FBgn0050345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG30345
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG30345 in Genome Data Viewer
Location:
45A13-45A13; 2-60 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9148689..9151892)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5036194..5039397)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44283

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Iron homeostasis in insects: Insights from Drosophila studies. Tang X, et al. IUBMB Life, 2013 Oct. PMID 24078394
  2. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. Paik D, et al. J Immunol, 2017 Jul 1. PMID 28539433, Free PMC Article
  3. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
  4. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
  5. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG30345-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9148689..9151892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165656.3 → NP_724760.2  uncharacterized protein Dmel_CG30345 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724760.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7R4, Q1EC10
    Conserved Domains (2) summary
    cd06174
    Location:121 → 472
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:102 → 437
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1EC10 Q1EC10

Gene LinkOut

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