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Pgant9 Polypeptide N-Acetylgalactosaminyltransferase 9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246627, updated on 9-Dec-2024

Summary

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Official Symbol
Pgant9provided by FlyBase
Official Full Name
Polypeptide N-Acetylgalactosaminyltransferase 9provided by FlyBase
Primary source
FLYBASE:FBgn0050463
Locus tag
Dmel_CG30463
See related
AllianceGenome:FB:FBgn0050463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15713; CG30463; CG8456; CG8463; Dmel\CG30463; dppGalNAcT9; pgant9; PGANT9
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation and sexual reproduction. Located in Golgi cisterna. Is expressed in several structures, including adult brain; adult brain cell body rind; epithelium; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including POC1B-GALNT4 (POC1B-GALNT4 readthrough) and GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pgant9 in Genome Data Viewer
Location:
53D1-53D4; 2-80 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16673235..16732916, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12560740..12620421, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 6 Neighboring gene long non-coding RNA:CR43104 Neighboring gene long non-coding RNA:CR44464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. O-Glycosylation of a male seminal fluid protein influences sperm binding and female postmating behavior. Zhang L, et al. PNAS Nexus, 2024 Aug. PMID 39189023, Free PMC Article
  2. A molecular switch orchestrates enzyme specificity and secretory granule morphology. Ji S, et al. Nat Commun, 2018 Aug 29. PMID 30158631, Free PMC Article
  3. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
  4. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article
  5. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences.
    Title: Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
polypeptide N-Acetylgalactosaminyltransferase 9
Names
CG30463-PA
CG30463-PB
CG30463-PC
CG30463-PD
CG30463-PE
Pgant9-PA
Pgant9-PB
Pgant9-PC
Pgant9-PD
Pgant9-PE
NP_001097341.1
NP_001097342.1
NP_001097343.1
NP_725602.1
NP_725603.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16673235..16732916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166188.2 → NP_725602.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725602.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1A6R7, A1A6V9, A8DYG1, A8DYG2, A8DYG3, Q0E950, Q8MRC9, Q9V7T0
    Related
    FBpp0086258
    Conserved Domains (4) summary
    cd02510
    Location:213 → 510
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:207 → 478
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:523 → 642
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:521 → 640
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_166189.2 → NP_725603.2  polypeptide N-Acetylgalactosaminyltransferase 9, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725603.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRC9
    Conserved Domains (4) summary
    cd02510
    Location:213 → 510
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:207 → 478
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:529 → 639
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:521 → 637
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_001103872.1 → NP_001097342.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1A6R7, A1A6V9, A8DYG1, A8DYG2, A8DYG3, Q0E950, Q8MRC9, Q9V7T0
    Conserved Domains (4) summary
    cd02510
    Location:213 → 510
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:207 → 478
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:523 → 642
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:521 → 640
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  4. NM_001103871.1 → NP_001097341.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRC9
    Conserved Domains (4) summary
    cd02510
    Location:213 → 510
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:207 → 478
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:529 → 639
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:521 → 637
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  5. NM_001103873.1 → NP_001097343.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRC9
    Conserved Domains (3) summary
    cd00161
    Location:146 → 256
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:138 → 254
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:1 → 127
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRC9.2 Q8MRC9

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