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Cyp12d1-p Cytochrome P450 12d1 proximal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246648, updated on 12-Dec-2024

Summary

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Official Symbol
Cyp12d1-pprovided by FlyBase
Official Full Name
Cytochrome P450 12d1 proximalprovided by FlyBase
Primary source
FLYBASE:FBgn0050489
Locus tag
Dmel_CG30489
See related
AllianceGenome:FB:FBgn0050489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12d1; 12D1; CG18240; CG30489; Cyp 12d1; CYP12A2; Cyp12d; cyp12d1; Cyp12d1; CYP12D1; cyp12d1-p; CYP12d1-p; Dmel\CG30489
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to DDT. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic/larval midgut primordium; and head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp12d1-p in Genome Data Viewer
Location:
47D4-47D4; 2-63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11117225..11121884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7004730..7009389, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45228 Neighboring gene luna Neighboring gene long non-coding RNA:CR46409 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12d1 distal Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. Mitchell CL, et al. PLoS One, 2014. PMID 24695618, Free PMC Article
  2. Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development. Rand MD, et al. Toxicology, 2012 Oct 9. PMID 22699155, Free PMC Article
  3. Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance. Jones RT, et al. Pest Manag Sci, 2010 Oct. PMID 20583201
  4. The biology of insecticidal activity and resistance. Perry T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21426939
  5. A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus. Li T, et al. Sci Rep, 2015 Dec 10. PMID 26656663, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyp12d1 is implicated by QTL mapped in both panels of DSPR RILs, is significantly upregulated in the presence of caffeine, and RNAi knockdown robustly decreases caffeine tolerance
    Title: Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.
  2. Transgenic flies, expressing the human ERRa-G allele, constitutively over-express Cyp12d1, Cyp6g2 and Cyp9c1.
    Title: A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster.
  3. The active site of CYP6G1 is significantly smaller than that of CYP6A2 or the CYP3A4.
    Title: Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to DDT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to insecticide IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 12d1 proximal
Names
CG30489-PA
CG30489-PB
Cyp12d1-p-PA
Cyp12d1-p-PB
cytochrome P450
cytochrome P450-12d1
NP_001286304.1
NP_610635.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11117225..11121884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299375.1 → NP_001286304.1  cytochrome P450 12d1 proximal, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286304.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P82712, Q8IH46, Q8T4K3
    UniProtKB/TrEMBL
    A0A0B4LF45
    Conserved Domains (1) summary
    cd11054
    Location:76 → 508
    CYP24A1-like; cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s

  2. NM_136791.6 → NP_610635.4  cytochrome P450 12d1 proximal, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610635.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P82712, Q8IH46, Q8T4K3
    UniProtKB/TrEMBL
    A0A0B4LF45
    Related
    FBpp0088437
    Conserved Domains (1) summary
    cd11054
    Location:76 → 508
    CYP24A1-like; cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LF45 A0A0B4LF45
P82712.3 P82712

Gene LinkOut

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