Klhl17 kelch-like family member 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl17provided by RGD
Official Full Name: kelch-like family member 17provided by RGD
Primary source: RGD:708444
See related: EnsemblRapid:ENSRNOG00000020302 AllianceGenome:RGD:708444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables POZ domain binding activity; actin filament binding activity; and molecular adaptor activity. Involved in actin cytoskeleton organization and regulation protein catabolic process at postsynapse. Located in actin cytoskeleton; dendrite cytoplasm; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 51.5), Adrenal (RPKM 40.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (172095701..172101945, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (166813482..166819949, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (173654238..173659706, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Actinfilin acts as a scaffold, linking kainate-type glutamate receptor subunit GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation.
Title: Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway.
a brain specific Kelch protein, which interacts with F-actin
Title: Actinfilin, a brain-specific actin-binding protein in postsynaptic density.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables POZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation protein catabolic process at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch-like protein 17

Names: actinfilin; kelch-like 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145671.2 → NP_663704.1 kelch-like protein 17

See identical proteins and their annotated locations for NP_663704.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8K430

UniProtKB/TrEMBL

A6IUX0

Related

ENSRNOP00000027547.5, ENSRNOT00000027547.7

Conserved Domains (5) summary

smart00612
Location:577 → 621

Kelch; Kelch domain

PHA03098
Location:90 → 556

PHA03098; kelch-like protein; Provisional

sd00038
Location:377 → 420

Kelch; KELCH repeat [structural motif]

cd18246
Location:51 → 189

BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

cl28903
Location:187 → 288

BACK; BACK (BTB and C-terminal Kelch) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

172095701..172101945 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109280.2 → XP_038965208.1 kelch-like protein 17 isoform X4

Conserved Domains (5) summary

smart00612
Location:537 → 581

Kelch; Kelch domain

PHA03098
Location:40 → 516

PHA03098; kelch-like protein; Provisional

sd00038
Location:327 → 370

Kelch; KELCH repeat [structural motif]

cd18246
Location:1 → 139

BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

cl28903
Location:137 → 238

BACK; BACK (BTB and C-terminal Kelch) domain
XM_063287161.1 → XP_063143231.1 kelch-like protein 17 isoform X3

Related

ENSRNOP00000106651.1, ENSRNOT00000172287.1
XM_008764336.3 → XP_008762558.1 kelch-like protein 17 isoform X2

Conserved Domains (6) summary

smart00612
Location:435 → 480

Kelch; Kelch domain

PHA03098
Location:90 → 577

PHA03098; kelch-like protein; Provisional

sd00038
Location:377 → 420

Kelch; KELCH repeat [structural motif]

pfam00651
Location:80 → 184

BTB; BTB/POZ domain

pfam01344
Location:376 → 421

Kelch_1; Kelch motif

pfam07707
Location:192 → 293

BACK; BTB And C-terminal Kelch
XM_006239521.4 → XP_006239583.1 kelch-like protein 17 isoform X1

Conserved Domains (5) summary

smart00612
Location:587 → 631

Kelch; Kelch domain

PHA03098
Location:90 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:377 → 420

Kelch; KELCH repeat [structural motif]

cd18246
Location:51 → 189

BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

cl28903
Location:187 → 288

BACK; BACK (BTB and C-terminal Kelch) domain
XM_039109283.2 → XP_038965211.1 kelch-like protein 17 isoform X6

Conserved Domains (4) summary

PHA03098
Location:90 → 489

PHA03098; kelch-like protein; Provisional

sd00038
Location:377 → 420

Kelch; KELCH repeat [structural motif]

cd18246
Location:51 → 189

BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

cl28903
Location:187 → 288

BACK; BACK (BTB and C-terminal Kelch) domain
XM_039109282.2 → XP_038965210.1 kelch-like protein 17 isoform X5

Conserved Domains (4) summary

PHA03098
Location:90 → 499

PHA03098; kelch-like protein; Provisional

sd00038
Location:377 → 421

Kelch; KELCH repeat [structural motif]

cd18246
Location:51 → 189

BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

cl28903
Location:187 → 288

BACK; BACK (BTB and C-terminal Kelch) domain