H2ac1 H2A clustered histone 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2ac1provided by RGD
Official Full Name: H2A clustered histone 1provided by RGD
Primary source: RGD:3854
See related: EnsemblRapid:ENSRNOG00000065352 AllianceGenome:RGD:3854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Th2a; Hist1h2aa
Summary: Predicted to enable DNA binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in female germ cell nucleus. Orthologous to human H2AC1 (H2A clustered histone 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41599195..41599672, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41171324..41171801, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43422454..43422846, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Animal physical conditioning increases hyper-acetylation of histones and increased the expression of NRF-1 and MEF2A genes.
Title: Exercise increases hyper-acetylation of histones on the Cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes.
Data indicate the effect of angiotensin II receptors' blockade on the macrophage infiltration and histone modifications occurring at the promoter region of monocyte chemoattractant protein (MCP-1) and transforming growth factor-beta (TGF-beta1).
Title: H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hist1 (e-PCR), detects polymorphism
- UniSTS:143347

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H2A type 4

Names: histone H2A, testis; histone cluster 1 H2A family member a; histone cluster 1, H2aa; testis-specific histone 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.