Wt1 WT1 transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24883, updated on 27-Nov-2024

Summary

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Official Symbol: Wt1provided by RGD
Official Full Name: WT1 transcription factorprovided by RGD
Primary source: RGD:3974
See related: EnsemblRapid:ENSRNOG00000013074 AllianceGenome:RGD:3974
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the human gene is mutated in a small subset of patients with Wilm's tumors. Authors of PMID:7926762 provide evidence that Wt1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Testes (RPKM 79.6), Uterus (RPKM 75.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Wt1 in Genome Data Viewer

Location:: 3q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (112019721..112068454)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (91566540..91613653)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (95133221..95180574)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1.
Title: MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1.
rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1).
Title: rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1).
Low WT1 expression is associated with membranous nephropathy.
Title: Improvement of membranous nephropathy by inhibition of miR-193a to affect podocytosis via targeting WT1.
this study shows that WT1 ameliorates podocyte injury via repression of EZH2/beta-catenin pathway in diabetic nephropathy
Title: WT1 ameliorates podocyte injury via repression of EZH2/β-catenin pathway in diabetic nephropathy.
Renal WT1 expression is decreased in spontaneously hypertensive rats before the development of hypertension.
Title: Changes in renal WT-1 expression preceding hypertension development.
High WT1 protein is associated with reduced ability to maintain podocyte integrity, rendering intrauterine growth restriction rats more susceptible for renal disease.
Title: Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations.
ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases. Thus, ATRA may provide a useful pharmacologic approach to decipher the
Title: Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease.
report of inhibition of FSHRexpression byWT1in ovarian tissue, and inhibition probably occurs via direct interaction with the FSHR promoter
Title: Regulation of FSH receptor expression by the Wilms' tumor 1 gene product (WT1) in immature rat granulosa cells.
The re-expression of WT1 and Pax2 in the tubular epithelial cells plays important roles in the promotion of epithelial-mesenchymal transition.
Title: WT1 and Pax2 re-expression is required for epithelial-mesenchymal transition in 5/6 nephrectomized rats and cultured kidney tubular epithelial cells.
Downregulation of diaphragmatic WT1 gene expression may impair diaphragmatic development in the nitrofen CDH model.
Title: Expression of the Wilm's tumor gene WT1 during diaphragmatic development in the nitrofen model for congenital diaphragmatic hernia.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wt1 (e-PCR), detects polymorphism
- UniSTS:265240

RH142234 (e-PCR)
- UniSTS:231483

Wt1 (e-PCR), detects polymorphism
- UniSTS:464700

Wt1 (e-PCR), detects polymorphism
- UniSTS:464701

Wt1 (e-PCR), detects polymorphism
- UniSTS:464702

Wt1 (e-PCR), detects polymorphism
- UniSTS:545875

PMC186395P1 (e-PCR)
- UniSTS:271706

WT1-2 (e-PCR)
- UniSTS:254075

GDB:371627 (e-PCR)
- UniSTS:156868

GDB:371639 (e-PCR)
- UniSTS:156872

d3rat26 (e-PCR)
- UniSTS:121849

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IEA Inferred from Electronic Annotation more info
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables C2H2 zinc finger domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded methylated DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded methylated DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded methylated DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables hemi-methylated DNA-binding	IEA Inferred from Electronic Annotation more info
enables hemi-methylated DNA-binding	ISO Inferred from Sequence Orthology more info
enables hemi-methylated DNA-binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Sertoli cell development	ISO Inferred from Sequence Orthology more info
involved_in adrenal cortex formation	ISO Inferred from Sequence Orthology more info
involved_in adrenal cortex formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in diaphragm development	ISO Inferred from Sequence Orthology more info
involved_in diaphragm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular basement membrane development	IEA Inferred from Electronic Annotation more info
involved_in glomerular basement membrane development	ISO Inferred from Sequence Orthology more info
involved_in glomerular basement membrane development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in gonad development	ISO Inferred from Sequence Orthology more info
involved_in gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell apoptotic process involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephric S-shaped body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric S-shaped body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric epithelium development	IEA Inferred from Electronic Annotation more info
involved_in metanephric epithelium development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of female gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of female gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric glomerular mesangial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in podocyte development	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in posterior mesonephric tubule development	ISO Inferred from Sequence Orthology more info
involved_in posterior mesonephric tubule development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of animal organ formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of animal organ formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
involved_in sex determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sex determination	ISO Inferred from Sequence Orthology more info
involved_in sex determination	ISO Inferred from Sequence Orthology more info
involved_in sex determination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in thorax and anterior abdomen determination	ISO Inferred from Sequence Orthology more info
involved_in thorax and anterior abdomen determination	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in visceral serous pericardium development	IEA Inferred from Electronic Annotation more info
involved_in visceral serous pericardium development	ISO Inferred from Sequence Orthology more info
involved_in visceral serous pericardium development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Wilms tumor protein homolog

Names: Wilms tumor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031534.2 → NP_113722.2 Wilms tumor protein homolog

See identical proteins and their annotated locations for NP_113722.2

Status: REVIEWED

Source sequence(s)

AA899753, CO382418, JAXUCZ010000003, X69716

UniProtKB/Swiss-Prot

P49952

UniProtKB/TrEMBL

A6HNW2

Related

ENSRNOP00000078611.1, ENSRNOT00000099117.2

Conserved Domains (3) summary

COG5048
Location:312 → 440

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:327 → 346

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:1 → 320

WT1; Wilm's tumor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

112019721..112068454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234622.5 → XP_006234684.1 Wilms tumor protein homolog isoform X3

UniProtKB/Swiss-Prot

P49952

Conserved Domains (4) summary

COG5048
Location:363 → 421

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:310 → 329

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:1 → 303

WT1; Wilm's tumour protein

pfam13465
Location:352 → 376

zf-H2C2_2; Zinc-finger double domain
XM_006234620.3 → XP_006234682.1 Wilms tumor protein homolog isoform X2

UniProtKB/Swiss-Prot

P49952

UniProtKB/TrEMBL

D3ZJ55

Related

ENSRNOP00000060038.3, ENSRNOT00000067940.5

Conserved Domains (4) summary

COG5048
Location:295 → 423

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:310 → 329

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:1 → 303

WT1; Wilm's tumour protein

pfam13465
Location:352 → 376

zf-H2C2_2; Zinc-finger double domain
XM_006234621.5 → XP_006234683.1 Wilms tumor protein homolog isoform X1

UniProtKB/Swiss-Prot

P49952

Conserved Domains (4) summary

COG5048
Location:380 → 438

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:327 → 346

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:1 → 320

WT1; Wilm's tumour protein

pfam13465
Location:369 → 393

zf-H2C2_2; Zinc-finger double domain
XM_063283112.1 → XP_063139182.1 Wilms tumor protein homolog isoform X8
XM_063283113.1 → XP_063139183.1 Wilms tumor protein homolog isoform X9
XM_063283110.1 → XP_063139180.1 Wilms tumor protein homolog isoform X5
XM_039104288.2 → XP_038960216.1 Wilms tumor protein homolog isoform X4

UniProtKB/TrEMBL

A6HNW3

Conserved Domains (3) summary

COG5048
Location:173 → 301

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:188 → 207

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:1 → 181

WT1; Wilm's tumor protein
XM_017591477.3 → XP_017446966.1 Wilms tumor protein homolog isoform X10

UniProtKB/TrEMBL

A6HNW3

Conserved Domains (3) summary

COG5048
Location:152 → 280

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:167 → 186

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:3 → 160

WT1; Wilm's tumor protein
XM_017591476.3 → XP_017446965.1 Wilms tumor protein homolog isoform X7

UniProtKB/TrEMBL

A6HNW3

Related

ENSRNOP00000086555.2, ENSRNOT00000102019.2

Conserved Domains (3) summary

COG5048
Location:237 → 295

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:184 → 203

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:3 → 177

WT1; Wilm's tumor protein
XM_039104289.2 → XP_038960217.1 Wilms tumor protein homolog isoform X6

UniProtKB/TrEMBL

A0A8I6GE58, A6HNW3

Conserved Domains (3) summary

COG5048
Location:169 → 297

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:184 → 203

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:3 → 177

WT1; Wilm's tumor protein
XM_063283114.1 → XP_063139184.1 Wilms tumor protein homolog isoform X11