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Stx1b syntaxin 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24923, updated on 27-Nov-2024

Summary

Official Symbol
Stx1bprovided by RGD
Official Full Name
syntaxin 1Bprovided by RGD
Primary source
RGD:3784
See related
EnsemblRapid:ENSRNOG00000019193 AllianceGenome:RGD:3784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Stx2; Stx1b2
Summary
Enables protein domain specific binding activity and signaling receptor binding activity. Involved in protein localization to membrane; regulation of exocytosis; and vesicle-mediated transport. Located in presynaptic membrane. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 280.3) and Uterus (RPKM 10.6) See more
Orthologs
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Genomic context

See Stx1b in Genome Data Viewer
Location:
1q37
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191846016..191864878, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182415544..182434385, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199251842..199270465, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SET domain containing 1A, histone lysine methyltransferase Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene uncharacterized LOC134483916 Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macropinocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of spontaneous neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle priming ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spontaneous neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle docking ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle docking ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking involved in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
syntaxin-1B
Names
P35B
Syntaxin 2
syntaxin 1B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012700.2NP_036832.1  syntaxin-1B

    See identical proteins and their annotated locations for NP_036832.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001, M95735
    UniProtKB/Swiss-Prot
    P61265
    UniProtKB/TrEMBL
    A0A8I5Y9T5, A6I9V0
    Related
    ENSRNOP00000026063.2, ENSRNOT00000026063.6
    Conserved Domains (2) summary
    pfam00804
    Location:29226
    Syntaxin
    pfam05739
    Location:227278
    SNARE; SNARE domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191846016..191864878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281069.1XP_063137139.1  syntaxin-1B isoform X1