Grpr gastrin releasing peptide receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grprprovided by RGD
Official Full Name: gastrin releasing peptide receptorprovided by RGD
Primary source: RGD:2750
See related: EnsemblRapid:ENSRNOG00000004124 AllianceGenome:RGD:2750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway; learning or memory; and social behavior. Predicted to be active in plasma membrane. Orthologous to human GRPR (gastrin releasing peptide receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 43.3), Kidney (RPKM 9.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (34630238..34670245)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30998425..31038442)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (32746259..32786266)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRPR down-regulation inhibits spermatogenesis through Ca[2+] mediated by PLCbeta/IP3R signaling pathway in long-term formaldehyde-exposed rats.
Title: GRPR down-regulation inhibits spermatogenesis through Ca(2+) mediated by PLCβ/IP3R signaling pathway in long-term formaldehyde-exposed rats.
peptidergic pathways comprise the core of a sigh control circuit that integrates physiological and perhaps emotional input to transform normal breaths into sighs
Title: The peptidergic control circuit for sighing.
These findings highlight the role of GRPR signaling in sepsis outcome.
Title: Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.
activation in the lumbosacral spinal cord required for ejaculation
Title: Activation of gastrin-releasing peptide receptors in the lumbosacral spinal cord is required for ejaculation in male rats.
Data suggest that the memory-impairing effects of gastrin-releasing peptide receptor antagonists might be mediated by inhibition of function and/or expression of neuronal bFGF or diminished bFGF signaling.
Title: Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus.
The mRNA for the major receptor subtype, GRP-R, was present in fetal and adult rat kidneys
Title: Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney.

Submit: New GeneRIF Correction

General gene information

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Markers

DXArb10 (e-PCR), detects polymorphism
- UniSTS:228388

Grpr (e-PCR), detects polymorphism
- UniSTS:495915

Grpr (e-PCR), detects polymorphism
- UniSTS:498771

DXWox17 (e-PCR)
- UniSTS:517792

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables bombesin receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in bombesin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory gaseous exchange	ISS Inferred from Sequence or Structural Similarity more info
involved_in psychomotor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to external biotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gastrin-releasing peptide receptor

Names: GRP-R; GRP-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.