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Chm CHM Rab escort protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24942, updated on 27-Nov-2024

Summary

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Official Symbol
Chmprovided by RGD
Official Full Name
CHM Rab escort proteinprovided by RGD
Primary source
RGD:2340
See related
EnsemblRapid:ENSRNOG00000000161 AllianceGenome:RGD:2340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in choroideremia. Orthologous to human CHM (CHM Rab escort protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 114.1), Kidney (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chm in Genome Data Viewer
Location:
Xq31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (82395463..82554249, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (78203200..78361996, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (84666900..84821775, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932431L22 gene like Neighboring gene uncharacterized LOC134484138 Neighboring gene uncharacterized LOC134484103 Neighboring gene tubulin, gamma 1, pseudogene 1 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 361 Neighboring gene U4 spliceosomal RNA Neighboring gene dachshund family transcription factor 2 Neighboring gene small nucleolar RNA SNORA31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Seabra MC, et al. Cell, 1992 Sep 18. PMID 1525821
  2. Cloning, mapping and characterization of the human RAB27A gene. Tolmachova T, et al. Gene, 1999 Oct 18. PMID 10571040
  3. cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Andres DA, et al. Cell, 1993 Jun 18. PMID 8513495
  4. [Autoregulation of cerebral blood flow]. Zderkiewicz E. Pol Tyg Lek, 1978 Jul 17. PMID 704419
  5. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RabGGTase has evolved from a GGTase-I-like molecule that 'learned' to interact with a recycling factor (GDI) that, in turn, eventually gave rise to REP1.
    Title: Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein geranylgeranylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein geranylgeranylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rab-protein geranylgeranyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Rab-protein geranylgeranyltransferase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Rab-protein geranylgeranyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Rab-protein geranylgeranyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rab proteins geranylgeranyltransferase component A 1
Names
CHM, Rab escort protein 1
REP-1
choroideraemia protein homolog
choroideremia (Rab escort protein 1)
choroideremia protein homolog
choroidermia
rab escort protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433732.1 → NP_001420661.1  rab proteins geranylgeranyltransferase component A 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  2. NM_017067.2 → NP_058763.2  rab proteins geranylgeranyltransferase component A 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    Related
    ENSRNOP00000000174.7, ENSRNOT00000000174.9

RNA

  1. NR_197594.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    82395463..82554249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099489.2 → XP_038955417.1  rab proteins geranylgeranyltransferase component A 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AG68
    Conserved Domains (1) summary
    cl21454
    Location:149 → 457
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_005497922.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37727.1 GenPept UniProtKB/Swiss-Prot:P37727

Gene LinkOut

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