bwa brain washing [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bwaprovided by FlyBase
Official Full Name: brain washingprovided by FlyBase
Primary source: FLYBASE:FBgn0045064
Locus tag: Dmel_CG13969
See related: AllianceGenome:FB:FBgn0045064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38B.6; ACER; BWA; CG13969; dacer; Dacer; DmACER; Dmel\CG13969
Summary: Enables N-acylsphingosine amidohydrolase activity. Involved in brain development and ceramide catabolic process. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including ACER2 (alkaline ceramidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20066391..20073719)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20066391..20073719)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables N-acylsphingosine amidohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables N-acylsphingosine amidohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingolipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info