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Kng2l1 kininogen 2-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25087, updated on 4-Jan-2025

Summary

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Symbol
Kng2l1provided by RGD
Full Name
kininogen 2-like 1provided by RGD
Primary source
RGD:1594590
See related
EnsemblRapid:ENSRNOG00000079266 AllianceGenome:RGD:1594590
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kng; Kng1; Kng2; Kngk; KINKG; KINKH; kininogen
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation; inflammatory response; and vasodilation. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Kng2l1 in Genome Data Viewer
Location:
11q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91483419..91507564)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77978795..78002976)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kininogen 2 Neighboring gene cyclin B1 interacting protein 1, pseudogene 2 Neighboring gene uncharacterized LOC108352357 Neighboring gene lactate dehydrogenase A, pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. Harris EL, et al. Mamm Genome, 1997 Oct. PMID 9321484
  2. Differing expression patterns and evolution of the rat kininogen gene family. Kitagawa H, et al. J Biol Chem, 1987 Feb 15. PMID 3029068
  3. Structure and expression of the genes for major acute phase alpha 1-protein (thiostatin) and kininogen in the rat. Fung WP, et al. J Biol Chem, 1987 Jul 5. PMID 2439509
  4. Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition. Kageyama R, et al. J Biol Chem, 1987 Feb 15. PMID 3818598
  5. Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor. Furuto-Kato S, et al. J Biol Chem, 1985 Oct 5. PMID 2413018

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury.
    Title: Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kininogen-1
Names
K-kininogen
kininogen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102418.1 → NP_001095888.1  kininogen-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001095888.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, and includes an alternate penultimate exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC088155
    UniProtKB/TrEMBL
    A6JS35, Q5M8A0
    Conserved Domains (2) summary
    smart00043
    Location:264 → 371
    CY; Cystatin-like domain
    pfam00031
    Location:144 → 238
    Cystatin; Cystatin domain

  2. NM_012741.1 → NP_036873.1  kininogen-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036873.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    L29428
    UniProtKB/Swiss-Prot
    P08933, P08934
    UniProtKB/TrEMBL
    A0A8I6GER1, A6JS39
    Related
    ENSRNOP00000086253.1, ENSRNOT00000102748.2
    Conserved Domains (2) summary
    smart00043
    Location:264 → 371
    CY; Cystatin-like domain
    pfam00031
    Location:144 → 238
    Cystatin; Cystatin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91483419..91507564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08934.1 GenPept UniProtKB/Swiss-Prot:P08934

Gene LinkOut

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