zpg zero population growth [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: zpgprovided by FlyBase
Official Full Name: zero population growthprovided by FlyBase
Primary source: FLYBASE:FBgn0024177
Locus tag: Dmel_CG10125
See related: AllianceGenome:FB:FBgn0024177
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10125; Dm-inx4; Dmel\CG10125; FBpp0076692; innexin4; inx-4; inx4; Inx4; Zpg
Summary: Predicted to enable gap junction channel activity. Involved in germ cell development; male germ-line stem cell population maintenance; and spermatogenesis. Located in gap junction and plasma membrane. Is expressed in several structures, including germarium; germline cell; germline cyst; ovariole; and pole plasm. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6604366..6606032, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6597466..6599132, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
Title: Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
innexin 4 was detected in the oolemma up to stage 8 and in nurse-cell membranes up to stage 12.
Title: Gap junctions in the ovary of Drosophila melanogaster: localization of innexins 1, 2, 3 and 4 and evidence for intercellular communication via innexin-2 containing channels.
in the male, localizes to the surface of spermatogonia; in the female,localizes to germ cell surfaces
Title: A germline-specific gap junction protein required for survival of differentiating early germ cells.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IC Inferred by Curator more info	PubMed
enables gap junction hemi-channel activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in gap junction	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed