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Ptpra protein tyrosine phosphatase, receptor type, A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25167, updated on 4-Jan-2025

Summary

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Official Symbol
Ptpraprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Aprovided by RGD
Primary source
RGD:3450
See related
EnsemblRapid:ENSRNOG00000021223 AllianceGenome:RGD:3450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRP
Summary
Enables protein tyrosine phosphatase activity. Involved in oligodendrocyte differentiation and positive regulation of oligodendrocyte differentiation. Predicted to be located in focal adhesion and membrane. Predicted to be part of receptor complex. Predicted to be active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 291.6), Heart (RPKM 200.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpra in Genome Data Viewer
Location:
3q36
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138103261..138212835)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117650146..117759744)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122976066..123084585)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene PC-esterase domain containing 1A Neighboring gene transmembrane 239 Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC134486445 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene oxytocin/neurophysin I prepropeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells. Moriyama T, et al. Biochem Biophys Res Commun, 1992 Oct 15. PMID 1417854
  2. Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2. Su J, et al. J Biol Chem, 1994 Jul 22. PMID 7518443
  3. SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent. Helmke S, et al. J Cell Sci, 1998 Aug. PMID 9683640
  4. Dynamics of protein-tyrosine phosphatases in rat adipocytes. Calera MR, et al. J Biol Chem, 2000 Mar 3. PMID 10692429
  5. Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. Wu CW, et al. Cancer Lett, 2006 Oct 8. PMID 16338072

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation
    Title: Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha.
  2. CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity.
    Title: Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
  3. protein tyrosine phosphatase PTP alpha has a role in induction of src kinase via protein kinase C
    Title: Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93561

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase alpha
Names
R-PTP-alpha
protein tyrosine phosphatase alpha
NP_036895.2
XP_006235068.1
XP_038960268.1
XP_063139209.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012763.2 → NP_036895.2  receptor-type tyrosine-protein phosphatase alpha precursor

    See identical proteins and their annotated locations for NP_036895.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081828
    UniProtKB/Swiss-Prot
    Q03348
    UniProtKB/TrEMBL
    F1M833, Q66HJ7
    Related
    ENSRNOP00000109915.1, ENSRNOT00000162829.1
    Conserved Domains (3) summary
    PHA03255
    Location:18 → 169
    PHA03255; BDLF3; Provisional
    smart00194
    Location:526 → 784
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:554 → 784
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138103261..138212835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235006.5 → XP_006235068.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

    See identical proteins and their annotated locations for XP_006235068.1

    UniProtKB/Swiss-Prot
    Q03348
    UniProtKB/TrEMBL
    A0A8J8YBN3
    Related
    ENSRNOP00000103665.1, ENSRNOT00000147780.1
    Conserved Domains (3) summary
    PHA03255
    Location:18 → 177
    PHA03255; BDLF3; Provisional
    cd14621
    Location:217 → 512
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:566 → 793
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  2. XM_039104340.2 → XP_038960268.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

    UniProtKB/Swiss-Prot
    Q03348
    UniProtKB/TrEMBL
    A0A8J8YBN3
    Conserved Domains (3) summary
    PHA03255
    Location:18 → 177
    PHA03255; BDLF3; Provisional
    cd14621
    Location:217 → 512
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:566 → 793
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  3. XM_063283139.1 → XP_063139209.1  receptor-type tyrosine-protein phosphatase alpha isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03348.1 GenPept UniProtKB/Swiss-Prot:Q03348

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