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Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 25179, updated on 27-Nov-2024

Summary

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Official Symbol
Idh3gprovided by RGD
Official Full Name
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaprovided by RGD
Primary source
RGD:2863
See related
EnsemblRapid:ENSRNOG00000055572 AllianceGenome:RGD:2863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IDH
Summary
Predicted to enable enzyme activator activity; isocitrate dehydrogenase (NAD+) activity; and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be located in nucleolus. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 1388.9), Muscle (RPKM 863.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Idh3g in Genome Data Viewer
Location:
Xq37
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156666573..156675482, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151515244..151524175, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156999803..157008735)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene plexin B3 Neighboring gene SRSF protein kinase 3 Neighboring gene signal sequence receptor subunit 4 Neighboring gene PDZ domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells. Yokoyama S, et al. Biochem Biophys Res Commun, 1997 Mar 27. PMID 9126338
  2. Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases. Nichols BJ, et al. Biochem J, 1993 Oct 15. PMID 8240232, Free PMC Article
  3. Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active site of pig heart NAD+-dependent isocitrate dehydrogenase. Saha A, et al. Biochemistry, 1989 Oct 17. PMID 2605193
  4. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 18. PMID 28098230, Free PMC Article
  5. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94551

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables isocitrate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables isocitrate dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isocitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isocitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) IEA
Inferred from Electronic Annotation
more info
  
part_of isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
Names
NAD (H)-specific isocitrate dehydrogenase gamma subunit
NAD(+)-specific ICDH subunit gamma
NAD+-isocitrate dehydrogenase gamma subunit
isocitrate dehydrogenase (NAD(+)) 3 gamma
isocitrate dehydrogenase 3 (NAD), gamma
isocitrate dehydrogenase 3, gamma
isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
isocitric dehydrogenase subunit gamma
NP_113739.1
XP_006229614.1
XP_006229615.1
XP_006229616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431553.1 → NP_001418482.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2K4Q0

  2. NM_031551.2 → NP_113739.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_113739.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P41565, P70577
    UniProtKB/TrEMBL
    Q5XIJ3
    Related
    ENSRNOP00000073128.3, ENSRNOT00000081819.3
    Conserved Domains (1) summary
    TIGR00175
    Location:52 → 383
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156666573..156675482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229552.5 → XP_006229614.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X1

    Related
    ENSRNOP00000096912.2, ENSRNOT00000113059.2
    Conserved Domains (1) summary
    TIGR00175
    Location:48 → 379
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  2. XM_006229553.5 → XP_006229615.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006229615.1

    UniProtKB/TrEMBL
    A6KRV1, A6KRV3
    Conserved Domains (1) summary
    TIGR00175
    Location:1 → 325
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  3. XM_006229554.4 → XP_006229616.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006229616.1

    UniProtKB/TrEMBL
    A6KRV1, A6KRV3
    Related
    ENSRNOP00000085780.1, ENSRNOT00000113588.2
    Conserved Domains (1) summary
    TIGR00175
    Location:1 → 325
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41565.2 GenPept UniProtKB/Swiss-Prot:P41565

Gene LinkOut

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