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St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25280, updated on 27-Nov-2024

Summary

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Official Symbol
St8sia1provided by RGD
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by RGD
Primary source
RGD:3679
See related
EnsemblRapid:ENSRNOG00000014018 AllianceGenome:RGD:3679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat8; Siat8a
Summary
Enables sialyltransferase activity. Predicted to be involved in N-glycan processing; oligosaccharide metabolic process; and protein glycosylation. Predicted to act upstream of or within cellular response to heat and positive regulation of epithelial cell proliferation. Predicted to be located in Golgi membrane. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 318.1), Brain (RPKM 55.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St8sia1 in Genome Data Viewer
Location:
4q44
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177513966..177651553, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175782989..175921338, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (177065266..177195942, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cytidine monophosphate N-acetylneuraminic acid synthetase Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene uncharacterized LOC134486862 Neighboring gene C2 calcium-dependent domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. Copani A, et al. J Neurosci, 2002 May 15. PMID 12019315, Free PMC Article
  2. The molecular cloning and expression of alpha 2,8-sialyltransferase (GD3 synthase) in a rat brain. Watanabe Y, et al. J Biochem, 1996 Nov. PMID 8982871
  3. Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility. Kamimura Y, et al. Int J Oncol, 2005 Feb. PMID 15645117
  4. Molecular cloning of cDNA for rat brain GD3-synthase. Zeng G, et al. Biochem Biophys Res Commun, 1996 Sep 13. PMID 8806633
  5. GD3 synthase gene found expressed in dental epithelium and shown to regulate cell proliferation. Yamada A, et al. Arch Oral Biol, 2005 Apr. PMID 15748692

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alpha2,8-sialyltransferase has roles in cell proliferation and mobility
    Title: Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Names
GD3 synthase
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1
Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase)
Sialyltransferase 8 A (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) GenBank no: U53883
alpha-2, 8-sialytransferase
alpha-2,8-sialyltransferase
alpha-N-acetylneuraminate: alpha-2,8-sialytransferase
sialyltransferase 8 (alpha-2 8-sialytransferase) A
NP_036945.2
XP_038963031.1
XP_038963032.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012813.3 → NP_036945.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

    See identical proteins and their annotated locations for NP_036945.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IMW7, G3V7T2, P70554, P97713
    Related
    ENSRNOP00000018999.4, ENSRNOT00000018999.7
    Conserved Domains (1) summary
    pfam00777
    Location:91 → 343
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    177513966..177651553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107103.2 → XP_038963031.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:21 → 201
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_039107104.2 → XP_038963032.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:2 → 196
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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