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Amacr alpha-methylacyl-CoA racemase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25284, updated on 27-Nov-2024

Summary

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Official Symbol
Amacrprovided by RGD
Official Full Name
alpha-methylacyl-CoA racemaseprovided by RGD
Primary source
RGD:3048
See related
EnsemblRapid:ENSRNOG00000018662 AllianceGenome:RGD:3048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Da1-8; Marc1
Summary
Enables alpha-methylacyl-CoA racemase activity. Involved in bile acid biosynthetic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 1549.5), Kidney (RPKM 1198.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amacr in Genome Data Viewer
Location:
2q16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61673291..61685381)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59946158..59958255)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60949276..60961342)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene C1q and TNF related 3 Neighboring gene solute carrier family 45, member 2 Neighboring gene relaxin family peptide receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer. Honma I, et al. J Transl Med, 2009 Dec 9. PMID 20003233, Free PMC Article
  2. Expression of alpha-methylacyl-CoA racemase correlates with histopathologic grading in noninvasive bladder cancer. Gunia S, et al. Virchows Arch, 2008 Aug. PMID 18648853
  3. Purification and properties of an alpha-methylacyl-CoA racemase from rat liver. Schmitz W, et al. Eur J Biochem, 1994 Jun 1. PMID 8020470
  4. Prognostic significance of alpha-methylacyl-coA racemase among men with high grade prostatic intraepithelial neoplasia in prostate biopsies. Stewart J, et al. J Urol, 2008 May. PMID 18343427
  5. Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression. Langner C, et al. Virchows Arch, 2006 Mar. PMID 16315020

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role of alpha-methylacyl-CoA racemase in bile acid synthesis
    Title: The role of alpha-methylacyl-CoA racemase in bile acid synthesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-methylacyl-CoA racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-methylacyl-CoA racemase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-methylacyl-CoA racemase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-methylacyl-CoA racemase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bile acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bile acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-methylacyl-CoA racemase
Names
2-arylpropionyl-CoA epimerase
2-methylacyl-CoA racemase
NP_036948.2
XP_038957703.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012816.2 → NP_036948.2  alpha-methylacyl-CoA racemase

    See identical proteins and their annotated locations for NP_036948.2

    Status: VALIDATED

    Source sequence(s)
    BC127505, FM061736
    UniProtKB/Swiss-Prot
    O09176, P70473
    UniProtKB/TrEMBL
    A6KJS2, G3V8F9
    Related
    ENSRNOP00000025323.3, ENSRNOT00000025323.7
    Conserved Domains (1) summary
    COG1804
    Location:3 → 373
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    61673291..61685381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101775.2 → XP_038957703.1  alpha-methylacyl-CoA racemase isoform X1

    Conserved Domains (1) summary
    COG1804
    Location:3 → 185
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70473.3 GenPept UniProtKB/Swiss-Prot:P70473

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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