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Mios meiosis regulator for oocyte development [ Mus musculus (house mouse) ]

Gene ID: 252875, updated on 27-Nov-2024

Summary

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Official Symbol
Miosprovided by MGI
Official Full Name
meiosis regulator for oocyte developmentprovided by MGI
Primary source
MGI:MGI:2182066
See related
Ensembl:ENSMUSG00000042447 AllianceGenome:MGI:2182066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metal ion binding activity. Involved in central nervous system myelin formation; oligodendrocyte progenitor proliferation; and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Is expressed in retina. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mios in Genome Data Viewer
Location:
6 A1; 6 3.51 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (8209111..8240573)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (8209111..8240573)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RNA binding protein with serine rich domain 1, pseudogene Neighboring gene predicted gene, 35446 Neighboring gene collagen, type XXVIII, alpha 1 Neighboring gene predicted gene, 35384 Neighboring gene STARR-seq mESC enhancer starr_15110 Neighboring gene STARR-seq mESC enhancer starr_15111 Neighboring gene STARR-seq mESC enhancer starr_15112 Neighboring gene STARR-positive B cell enhancer ABC_E1064 Neighboring gene STARR-positive B cell enhancer mm9_chr6:8225128-8225429 Neighboring gene UMAP1-MVP12 associated (UMA) domain containing 1 Neighboring gene replication protein A3 Neighboring gene STARR-seq mESC enhancer starr_15115 Neighboring gene STARR-seq mESC enhancer starr_15116 Neighboring gene predicted gene, 46952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GATOR2 complex-mediated amino acid signaling regulates brain myelination. Yu Z, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35022234, Free PMC Article
  2. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  3. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
  4. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25527

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligodendrocyte progenitor proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of GATOR2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GATOR2 complex protein MIOS
Names
GATOR complex protein MIOS
WD repeat-containing protein mio
missing oocyte, meiosis regulator, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145374.2 → NP_663349.2  GATOR2 complex protein MIOS

    See identical proteins and their annotated locations for NP_663349.2

    Status: VALIDATED

    Source sequence(s)
    AK034623, AK079844, BP765255, BQ876300, BU510538, BY064617, CD807728, CX565910
    Consensus CDS
    CCDS39425.1
    UniProtKB/Swiss-Prot
    E9QM00, Q8VE19
    Related
    ENSMUSP00000039301.8, ENSMUST00000040017.8
    Conserved Domains (3) summary
    COG2319
    Location:97 → 368
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    8209111..8240573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166131.1 → XP_036022024.1  GATOR2 complex protein MIOS isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:97 → 368
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:697 → 791
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

  2. XM_036166132.1 → XP_036022025.1  GATOR2 complex protein MIOS isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:97 → 368
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:697 → 773
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

  3. XM_036166130.1 → XP_036022023.1  GATOR2 complex protein MIOS isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 876
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:112 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036166129.1 → XP_036022022.1  GATOR2 complex protein MIOS isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 876
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:112 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004942957.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE19.2 GenPept UniProtKB/Swiss-Prot:Q8VE19

Gene LinkOut

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