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Foxd4 forkhead box D4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252886, updated on 4-Jan-2025

Summary

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Official Symbol
Foxd4provided by RGD
Official Full Name
forkhead box D4provided by RGD
Primary source
RGD:621716
See related
AllianceGenome:RGD:621716
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HFH-6; FREAC-5
Summary
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to several human genes including FOXD4 (forkhead box D4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See Foxd4 in Genome Data Viewer
Location:
1q51
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231983872..231985565, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (222557494..222559189, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242808886..242810186, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5 Neighboring gene Zn regulated GTPase metalloprotein activator 1A Neighboring gene uncharacterized LOC102556915 Neighboring gene uncharacterized LOC134483982

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation. Wang LJ, et al. Exp Biol Med (Maywood), 2018 Feb. PMID 29307282, Free PMC Article
  2. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Clevidence DE, et al. Proc Natl Acad Sci U S A, 1993 May 1. PMID 7683413, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tentative conclusions were drawn that FOXD3/FOXD4 is expressed in the hindgut in rat embryos and is upregulated in anorectal malformation.
    Title: FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
forkhead box protein D4; LOW QUALITY PROTEIN: forkhead box protein D4
Names
forkhead-related protein FKHL9
forkhead-related transcription factor 5
hepatocyte nuclear factor 3 forkhead homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    231983872..231985565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001055972.6 → XP_001055972.2  LOW QUALITY PROTEIN: forkhead box protein D4

    See identical proteins and their annotated locations for XP_001055972.2

    UniProtKB/TrEMBL
    A0A8I6A8H7
    Conserved Domains (1) summary
    pfam00250
    Location:103 → 189
    Forkhead; Forkhead domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63249.1 GenPept UniProtKB/Swiss-Prot:Q63249

Gene LinkOut

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