Mrgprx3 MAS related GPR family member X3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrgprx3provided by RGD
Official Full Name: MAS related GPR family member X3provided by RGD
Primary source: RGD:632282
See related: EnsemblRapid:ENSRNOG00000014227 AllianceGenome:RGD:632282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MrgA; Mgrg1; Mrga10; Mrgpra
Summary: Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX3 (MAS related GPR family member X3) and MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 9.7), Kidney (RPKM 7.4) and 7 other tissues See more
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Genomic context

Location:: 1q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106857685..106883199, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (97720377..97746953, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (103298172..103323476, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[The distribution of Mas-related G protein-coupled receptor A in cerebrospinal fluid-contacting nucleus of normal rats and its up-regulation in neuropathic pain].
Title: [The distribution of Mas-related G protein-coupled receptor A in cerebrospinal fluid-contacting nucleus of normal rats and its up-regulation in neuropathic pain].
Results validate the predicted structure for MrgA and should be useful for seeking other small molecule agonists and antagonists.
Title: Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.
Kinetics of adenine binding to the adenine receptor of the rat brain cortex.
Title: Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member A

Names: G-protein coupled receptor; G-protein coupled receptor; rc 56.1.3; MAS-related G-protein coupled receptor, member A; MAS-related GPR, member X3; Mas-related G protein-coupled receptor g1; Mas-related gene A; adenine receptor; nuclear receptor MrgA10 RF-amide G protein-coupled receptor; rc 56.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145787.2 → NP_665730.2 mas-related G-protein coupled receptor member A

See identical proteins and their annotated locations for NP_665730.2

Status: PROVISIONAL

Source sequence(s)

BC089774

UniProtKB/Swiss-Prot

Q5FVU1, Q7TN49, Q91YB7

UniProtKB/TrEMBL

A0A0H2UHL4, W8W3K1

Related

ENSRNOP00000019051.6, ENSRNOT00000019051.7

Conserved Domains (1) summary

pfam00001
Location:57 → 289

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

106857685..106883199 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101537.2 → XP_038957465.1 mas-related G-protein coupled receptor member A isoform X1

Conserved Domains (2) summary

cd14964
Location:49 → 74

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:33 → 167

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily