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Il13ra1 interleukin 13 receptor subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252963, updated on 4-Jan-2025

Summary

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Official Symbol
Il13ra1provided by RGD
Official Full Name
interleukin 13 receptor subunit alpha 1provided by RGD
Primary source
RGD:628741
See related
EnsemblRapid:ENSRNOG00000013170 AllianceGenome:RGD:628741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables interleukin-13 receptor activity. Involved in positive regulation of B cell proliferation and positive regulation of immunoglobulin production. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human IL13RA1 (interleukin 13 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 464.4), Lung (RPKM 287.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il13ra1 in Genome Data Viewer
Location:
Xq34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (120213670..120294777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (115348822..115408682)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (122724081..122783801)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene dedicator of cytokinesis 11 Neighboring gene uncharacterized LOC134484095 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene U6 spliceosomal RNA Neighboring gene LON peptidase N-terminal domain and ring finger 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population. Ahmed S, et al. Exp Clin Immunogenet, 2000. PMID 10686479
  2. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. Konstantinidis AK, et al. Eur Respir J, 2007 Jul. PMID 17392323
  3. Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. Wongpiyabovorn J, et al. J Dermatol Sci, 2003 Oct. PMID 14527737
  4. IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice. Blease K, et al. J Immunol, 2001 Dec 1. PMID 11714828
  5. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Graham BB, et al. Am J Pathol, 2010 Sep. PMID 20671265, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC105309

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables interleukin-13 receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in interleukin-13-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-13 receptor subunit alpha-1
Names
interleukin 13 receptor, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145789.3 → NP_665732.2  interleukin-13 receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_665732.2

    Status: VALIDATED

    Source sequence(s)
    BC093615, JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2JZB2, Q561K3, Q8VHC2
    Conserved Domains (2) summary
    cd00063
    Location:225 → 335
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:127 → 221
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    120213670..120294777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279821.1 → XP_063135891.1  interleukin-13 receptor subunit alpha-1 isoform X1

    Related
    ENSRNOP00000087106.2, ENSRNOT00000112175.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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