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tco89 TORC1 subunit Tco89 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538993, updated on 18-Sep-2024

Summary

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Official Symbol
tco89
Official Full Name
TORC1 subunit Tco89
Primary source
PomBase:SPCC162.12
Locus tag
SPOM_SPCC162.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPCC1753.06c
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Genomic context

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See tco89 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1552594..1554497, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene meiotic recombination protein Rec7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 3'(2'),5'-bisphosphate nucleotidase/inositol-1,4-bisphosphate 1-phosphatase Neighboring gene zinc finger C3HC-type containing RNA export factor Rsm1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uridine kinase/uracil phosphoribosyltransferase Neighboring gene serine/threonine protein kinase Ppk33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe. Panigrahi L, et al. Fungal Genet Biol, 2023 Jan. PMID 36481249
  2. TORC1 of fission yeast is rapamycin-sensitive. Takahara T, et al. Genes Cells, 2012 Aug. PMID 22762302
  3. The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast. Reidman S, et al. J Biol Chem, 2019 Nov 29. PMID 31641022, Free PMC Article
  4. Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase. Nakashima A, et al. J Cell Sci, 2012 Dec 1. PMID 22976295, Free PMC Article
  5. The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Ikai N, et al. Open Biol, 2011 Nov. PMID 22645648, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. esults reveal the contribution of the key metabolic enzyme cytosolic form of aspartate aminotransferase (Caa1) to TORC1 activity in fission yeast Schizosaccharomyces pombe.
    Title: The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.
  2. Our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.
    Title: TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
  3. The results provide convincing evidence that /Psk1/Rps6 constitutes a nutrient-dependent signaling pathway in fission yeast.
    Title: Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
  4. Growth of wild-type fission yeast cells becomes sensitive to rapamycin in a TORC1-dependent manner when these cells are treated with caffeine.
    Title: TORC1 of fission yeast is rapamycin-sensitive.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TORC1 signaling IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 

General protein information

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Preferred Names
TORC1 subunit Tco89

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1552594..1554497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023222.3 → NP_588232.1  TORC1 subunit Tco89 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588232.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74428, Q7LL02
    Conserved Domains (1) summary
    pfam10452
    Location:32 → 408
    TCO89; TORC1 subunit TCO89
Nucleotide Protein
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