U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cgs2 dual-specifity cAMP/cGMP phosphodiesterase Cgs2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539207, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
cgs2
Official Full Name
dual-specifity cAMP/cGMP phosphodiesterase Cgs2
Primary source
PomBase:SPCC285.09c
Locus tag
SPOM_SPCC285.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
pde1
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cgs2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003421.2 (1810337..1812643, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene wtf antidote-like meiotic drive suppressor Wtf18 Neighboring gene coatomer delta subunit Ret2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mochizuki N, et al. Mol Gen Genet, 1992 May. PMID 1318497
  2. The Schizosaccharomyces pombe pde1/cgs2 gene encodes a cyclic AMP phosphodiesterase. Matviw H, et al. Biochem Biophys Res Commun, 1993 Jul 15. PMID 8392846
  3. Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Isshiki T, et al. Genes Dev, 1992 Dec. PMID 1340462
  4. The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle. Wu SY, et al. Mol Cell Biol, 1995 Mar. PMID 7862141, Free PMC Article
  5. Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases. Demirbas D, et al. Cell Signal, 2011 Mar. PMID 21118717, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+
    Title: Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.
  2. PDE activity in S. pombe may be coordinately regulated with adenylate cyclase activity as part of the feedback regulation mechanism to limit the cAMP response to glucose detection.
    Title: Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cAMP catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glucose mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dual-specifity cAMP/cGMP phosphodiesterase Cgs2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1810337..1812643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023328.3 → NP_588337.1  dual-specifity cAMP/cGMP phosphodiesterase Cgs2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588337.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36599
    Conserved Domains (1) summary
    COG5212
    Location:1 → 346
    PDE1; cAMP phosphodiesterase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials