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dsc5 UBA/UAS domain-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539260, updated on 18-Sep-2024

Summary

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Official Symbol
dsc5
Official Full Name
UBA/UAS domain-containing protein
Primary source
PomBase:SPCC285.11
Locus tag
SPOM_SPCC285.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ucp10
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Genomic context

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See dsc5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1816085..1818403)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SPRY domain membrane protein, specificity factor required for ubiquitination Ear1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U6 snRNP-associated protein Lsm7 Neighboring gene nucleoporin Nup60 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2. Hwang J, et al. Biochem J, 2016 Aug 15. PMID 27274088, Free PMC Article
  2. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. Burr R, et al. J Biol Chem, 2017 Mar 31. PMID 28202541, Free PMC Article
  3. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article
  4. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Chong R, et al. J Biol Chem, 2013 Jul 12. PMID 23729666, Free PMC Article
  5. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. Stewart EV, et al. J Biol Chem, 2012 Jan 2. PMID 22086920, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Dsc E3 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBA/UAS domain-containing protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1816085..1818403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023330.3 → NP_588339.1  UBA/UAS domain-containing protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588339.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74498
    Conserved Domains (2) summary
    smart00594
    Location:111 → 237
    UAS; UAS domain
    pfam00789
    Location:322 → 425
    UBX; UBX domain
Nucleotide Protein
Heading Accession and Version

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