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ccq1 shelterin complex HEAT repeat subunit Ccq1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539352, updated on 18-Sep-2024

Summary

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Official Symbol
ccq1
Official Full Name
shelterin complex HEAT repeat subunit Ccq1
Primary source
PomBase:SPCC188.07
Locus tag
SPOM_SPCC188.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ccq1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1486140..1488678)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene signal recognition particle subunit Srp54 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Tomita K, et al. Genes Dev, 2008 Dec 15. PMID 19141478, Free PMC Article
  2. Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. van Emden TS, et al. EMBO Rep, 2019 Jan. PMID 30420521, Free PMC Article
  3. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks. Audry J, et al. Nucleic Acids Res, 2024 Apr 24. PMID 38321948, Free PMC Article
  4. An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome. Flory MR, et al. Mol Cell, 2004 Nov 19. PMID 15546621
  5. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. Shi S, et al. Life Sci Alliance, 2021 Nov. PMID 34493579, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
    Title: Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.
  2. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres.
    Title: Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres.
  3. We propose that Ccq1 and fragile subtelomeres co-evolved to regulate telomere plasticity by controlling nucleosome occupancy and genome stability.
    Title: Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
  4. Data suggest that telomere maintenance protein Ccq1 (Ccq1)-Est1 recruits telomerase to mediate telomere extension, whilst elongated telomeric DNA recruits Ccq1 with the chromatin-remodelling complexes, which in turn releases telomerase from the telomere.
    Title: Fission yeast Ccq1 is a modulator of telomerase activity.
  5. Together, these data provide a first glimpse into the architectural design of the Ccq1-Tpz1-Poz1 complex and reveals unique interactions that are important in maintaining the Schizosaccharomyces pombe telomere in a non-extendible state.
    Title: Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.
  6. Tpz1-Ccq1 interaction is required for Ccq1 Thr93 phosphorylation and telomerase recruitment.
    Title: Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.
  7. Tpz1 also participates in the activation of telomeres to the extendible state via its interaction with Ccq1
    Title: Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.
  8. data suggest that Ccq1p and condensins Cut3p and Cut14p collaborate to mediate resolution of telomeres in mitosis and regulate intertelomeric clustering during interphase
    Title: Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.
  9. The loss of Ccq1 results in progressive telomere shortening and persistent ATR-dependent activation of Chk1
    Title: Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere capping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere-telomerase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
part_of shelterin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of telomere cap complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shelterin complex HEAT repeat subunit Ccq1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1486140..1488678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023200.3 → NP_588210.1  shelterin complex HEAT repeat subunit Ccq1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588210.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10432
    Conserved Domains (3) summary
    pfam07874
    Location:47 → 97
    DUF1660; Prophage protein (DUF1660)
    pfam11496
    Location:129 → 415
    HDA2-3; Class II histone deacetylase complex subunits 2 and 3
    pfam13863
    Location:520 → 608
    DUF4200; Domain of unknown function (DUF4200)
Nucleotide Protein
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