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rpt3 proteasome regulatory subunit Rpt3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539539, updated on 18-Sep-2024

Summary

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Official Symbol
rpt3
Official Full Name
proteasome regulatory subunit Rpt3
Primary source
PomBase:SPCC576.10c
Locus tag
SPOM_SPCC576.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rpt3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (2097289..2098866, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS5 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS10 Neighboring gene 60S ribosomal protein eL15 Neighboring gene FANCM-MHF complex subunit Mhf2 Neighboring gene Swr1 complex subunit Swc5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of 15 New Bypassable Essential Genes of Fission Yeast. Takeda A, et al. Cell Struct Funct, 2019 Sep 27. PMID 31474649, Free PMC Article
  2. The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin. Kitagawa T, et al. Nat Commun, 2014 Apr 7. PMID 24710126
  3. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Jossé L, et al. Biochem J, 2006 Jan 1. PMID 16149916, Free PMC Article
  4. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307589, Free PMC Article
  5. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rpt3 mutation disrupts CENP-A distribution due to loss of centromeric chromatin association.
    Title: The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome regulatory subunit Rpt3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2097289..2098866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023428.3 → NP_588437.1  proteasome regulatory subunit Rpt3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588437.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74894
    Conserved Domains (3) summary
    PTZ00454
    Location:2 → 389
    PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
    pfam00004
    Location:171 → 303
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21455
    Location:99 → 235
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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