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rum1 CDK inhibitor Rum1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539640, updated on 18-Sep-2024

Summary

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Official Symbol
rum1
Official Full Name
CDK inhibitor Rum1
Primary source
PomBase:SPBC32F12.09
Locus tag
SPOM_SPBC32F12.09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rum1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2799677..2801917)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DASH complex subunit Duo1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phosphoglucomutase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement of PP2A-B56(Par1) for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C(Ste9) during Pre-Start G1 in S. pombe. Stonyte V, et al. iScience, 2020 May 22. PMID 32361273, Free PMC Article
  2. Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1. Yu EY, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376070
  3. Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast. Labib K, et al. J Cell Sci, 1995 Oct. PMID 7593289
  4. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Moreno S, et al. Nature, 1994 Jan 20. PMID 8121488
  5. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Correa-Bordes J, et al. Cell, 1995 Dec 15. PMID 8521500

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity EXP
Inferred from Experiment
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic G1 cell size control checkpoint signaling EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic G1 cell size control checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
CDK inhibitor Rum1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2799677..2801917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022071.3 → NP_596152.1  CDK inhibitor Rum1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596152.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74373, P40380
Nucleotide Protein
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