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prp2 U2 small nuclear RNA auxiliary factor small subunit, U2AF-59 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539645, updated on 18-Sep-2024

Summary

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Official Symbol
prp2
Official Full Name
U2 small nuclear RNA auxiliary factor small subunit, U2AF-59
Primary source
PomBase:SPBC146.07
Locus tag
SPOM_SPBC146.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mis11; ods1; uaf1
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Genomic context

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See prp2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1013310..1015179)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene fanconi-associated nuclease 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation initiation factor eIF1A-like Neighboring gene histone demethylase SWIRM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns. Hümmer S, et al. Cell Rep, 2021 Oct 26. PMID 34706246
  2. Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF. Sridharan V, et al. Mol Cell Biol, 2011 Feb. PMID 21149581, Free PMC Article
  3. The small subunit of the splicing factor U2AF is conserved in fission yeast. Wentz-Hunter K, et al. Nucleic Acids Res, 1996 May 15. PMID 8657565, Free PMC Article
  4. Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo. Webb CJ, et al. Mol Biol Cell, 2005 Feb. PMID 15548596, Free PMC Article
  5. A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit. Yoshida H, et al. Genes Dev, 2015 Aug 1. PMID 26215567, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
    Title: Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
  2. performed mRNA profiling for splicing in the U2AF(59) (prp2.1) temperature-sensitive mutant. Introns show a range of splicing defects in the mutant strain.
    Title: Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA branch site recognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA cis splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2AF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of commitment complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
U2 small nuclear RNA auxiliary factor small subunit, U2AF-59

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1013310..1015179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021303.3 → NP_595396.1  U2 small nuclear RNA auxiliary factor small subunit, U2AF-59 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595396.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36629, Q9UTU7
    Conserved Domains (3) summary
    cd12232
    Location:417 → 505
    RRM3_U2AF65; RNA recognition motif 3 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
    TIGR01642
    Location:22 → 517
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:310 → 381
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version

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