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spt8 SAGA complex subunit Spt8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539775, updated on 18-Sep-2024

Summary

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Official Symbol
spt8
Official Full Name
SAGA complex subunit Spt8
Primary source
PomBase:SPBC14C8.17c
Locus tag
SPOM_SPBC14C8.17C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sep9
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Genomic context

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See spt8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (2233461..2235778, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene triglyceride lipase-cholesterol esterase Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein subunit S45 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TPR repeat-containing protein Oca3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage. Batta G, et al. FEMS Yeast Res, 2009 Aug. PMID 19473263
  2. Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation. Grallert A, et al. Yeast, 1999 Jun 15. PMID 10392445
  3. The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast. Takahashi H, et al. J Biol Chem, 2012 Nov 2. PMID 22992726, Free PMC Article
  4. Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. Elmore ZC, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948786, Free PMC Article
  5. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. Bao K, et al. Genes Dev, 2019 Jan 1. PMID 30573453, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that SAGA plays distinct roles in the control of the switch from proliferation to differentiation in S. pombe through the dynamic and opposing activities of Gcn5 and Spt8.
    Title: The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
SAGA complex subunit Spt8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2233461..2235778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021828.3 → NP_595920.1  SAGA complex subunit Spt8 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595920.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60097
    Conserved Domains (4) summary
    COG2319
    Location:120 → 473
    WD40; WD40 repeat [General function prediction only]
    pfam05285
    Location:35 → 95
    SDA1; SDA1
    sd00039
    Location:121 → 161
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:120 → 469
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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Research Materials