cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: cdc2
Official Full Name: cyclin-dependent protein kinase Cdk1/Cdc2
Primary source: PomBase:SPBC11B10.09
Locus tag: SPOM_SPBC11B10.09
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: cdk1
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Genomic context

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See cdc2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003423.3 (1500208..1502095)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
Title: Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
Substrate Phosphorylation Rates as an In Vivo Measurement of Kinase Activity.
Title: Substrate Phosphorylation Rates as an In Vivo Measurement of Kinase Activity.
study resolves the conserved mechanisms of chromosomal passenger complex targeting to centromeres, highlighting a key role of Cdk1-cyclin B in chromosome bi-orientation
Title: Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Cdk1 phosphorylation of formin Cdc12 antagonizes its interaction with Cdc15 and thereby opposes Cdc12's contractile ring localization. These results are consistent with a general role for Cdk1 in inhibiting cytokinesis until chromosome segregation is complete.
Title: Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
fission yeast Wee1 is a major kinase regulating Cdc2 activity in S phase
Title: Consequences of abnormal CDK activity in S phase.
Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription.
Title: Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription.
Wee1 phosphorylates Cdc2 Tyr15 which leads to replication slowdown in the fission yeast under nitrosative stress.
Title: Nitrosative stress induces a novel intra-S checkpoint pathway in Schizosaccharomyces pombe involving phosphorylation of Cdc2 by Wee1.
unphosphorylated Cdc2 contributes to the DNA damage response via Chk1 while the Y15 modified phospho-forms regulate cell cycle progression.
Title: Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
Cdc31 phosphorylation on serine 15 in a Cdk1 (encoded by cdc2) consensus site is required for the dissociation of a significant pool of Sfi1 from the bridge and timely segregation of SPBs at mitotic onset.
Title: Cell cycle control of spindle pole body duplication and splitting by Sfi1 and Cdc31 in fission yeast.
Cdk1 phosphorylates residues in the C terminus of Xlf1 over the course of the cell cycle.
Title: Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA damage checkpoint signaling	EXP Inferred from Experiment more info	PubMed
involved_in mitotic G1 cell size control checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic G1 cell size control checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of exit from mitosis	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of mitotic DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cytokinesis	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic telomere tethering at nuclear periphery	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of primary cell septum biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in nuclear pore complex assembly	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of initiation of premeiotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinetochore assembly	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle DNA replication	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic sister chromatid biorientation	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of mitotic sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of septation initiation signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle switching, mitotic to meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment or maintenance of bipolar cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of linear element maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to meiotic DNA replication checkpoint signaling	EXP Inferred from Experiment more info	PubMed
involved_in response to mitotic DNA integrity checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mitotic G2 DNA damage checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mitotic G2 DNA damage checkpoint signaling	IPI Inferred from Physical Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, telomeric repeat region	EXP Inferred from Experiment more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	EXP Inferred from Experiment more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	EXP Inferred from Experiment more info	PubMed
is_active_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle pole body	EXP Inferred from Experiment more info	PubMed
is_active_in mitotic spindle	EXP Inferred from Experiment more info	PubMed
is_active_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	EXP Inferred from Experiment more info	PubMed
is_active_in new mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolar peripheral inclusion body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in old mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-dependent protein kinase Cdk1/Cdc2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

1500208..1502095

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356226.2 → NP_001342995.1 cyclin-dependent protein kinase Cdk1/Cdc2 [Schizosaccharomyces pombe]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P04551

Conserved Domains (1) summary

cd07835
Location:4 → 293

STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase