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trx2 thioredoxin Trx2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539898, updated on 18-Sep-2024

Summary

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Official Symbol
trx2
Official Full Name
thioredoxin Trx2
Primary source
PomBase:SPBC12D12.07c
Locus tag
SPOM_SPBC12D12.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See trx2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (2317361..2318530, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene calcium-binding subfamily carrier protein Neighboring gene DNA polymerase zeta Rev7 Neighboring gene ncRNA Neighboring gene cyclin CycC-like Srb mediator subunit Srb11 Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe. Song JY, et al. Eukaryot Cell, 2008 Dec. PMID 18849471, Free PMC Article
  2. Characterization and regulation of a second gene encoding thioredoxin from the fission yeast. Lee YJ, et al. Biochim Biophys Acta, 2002 May 3. PMID 12020831
  3. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174
  4. Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Song JY, et al. Eukaryot Cell, 2006 Nov. PMID 16950927, Free PMC Article
  5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trx2 protects mitochondrial components against thiol-oxidative damage and supports urea cycle.
    Title: Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-disulfide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion HDA PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin Trx2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2317361..2318530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021863.3 → NP_595954.2  thioredoxin Trx2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595954.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94504
    Conserved Domains (1) summary
    cd02947
    Location:39 → 122
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein
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