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ade8 adenylosuccinate lyase Ade8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539985, updated on 18-Sep-2024

Summary

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Official Symbol
ade8
Official Full Name
adenylosuccinate lyase Ade8
Primary source
PomBase:SPBC14F5.09c
Locus tag
SPOM_SPBC14F5.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ade8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (4172822..4175500, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin ligase Doa10 Neighboring gene ncRNA Neighboring gene mediator complex subunit Med7 Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sorting nexin Snx41

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro. Juang RH, et al. Arch Biochem Biophys, 1993 Aug 1. PMID 8346915
  2. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
  3. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article
  4. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
  5. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' AMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
adenylosuccinate lyase Ade8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4172822..4175500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022661.3 → NP_596735.1  adenylosuccinate lyase Ade8 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596735.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60105
    Conserved Domains (2) summary
    cd03302
    Location:11 → 449
    Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
    COG0015
    Location:11 → 460
    PurB; Adenylosuccinate lyase [Nucleotide transport and metabolism]
Nucleotide Protein
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